Living with male pattern baldness can be stressful and embarrassing. Previous studies have shown baldness to have a complex genetic architecture, with particularly strong signals on the X chromosome. However, these studies have been limited by small sample sizes. Here, we present the largest genome-wide study of baldness to date, using data from over 52,000 male participants in the UK Biobank study. We identify over 200 novel findings. We also split our dataset in two to build and apply a genetic predictor of baldness. Of those with a polygenic score below the median, 14% had severe hair loss and 39% no hair loss. By contrast, of those with a polygenic score in the top 10%, 58% reported moderate-to-severe hair loss.
The relationship of cognitive function and negative emotions with morbidity and mortality: an aetiological investigation
To understand why poorer cognitive function and negative emotional factors are typically associated with poorer health and increased mortality.
The explanation for the associations between poorer cognitive function or negative emotions and adverse health outcomes are unclear. In general, adjustment for potentially confounding or mediating factors has had little attenuating effect on the associations, but many studies have lacked comprehensive data on such factors. It is important that we investigate the biological determinants of the relationships between cognitive function and negative emotional states and traits, and later health outcomes. Publications:
1. G Davies, et al. Genome-wide association study of cognitive functions and educational attainment in UK Biobank (N=112151)
2. WD Hill, et al.Molecular genetic aetiology of general cognitive function is enriched in evolutionarily conserved regions
|Lead investigator:||Catharine Gale|
|Lead institution:||University of Edinburgh|
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