Cognitive impairment and COPD
Chronic Obstructive Pulmonary Disease(COPD) is a progressive disease, characterized by a gradual decline in lung function. It is a major cause of morbidity and mortality worldwide. Patients with COPD often suffer from comorbidities, such as cardiovascular disease, osteoporosis, and psychological symptoms. Previous studies suggest that cognitive functioning might be impaired in patients with COPD and may even predict mortality and disability. However, the exact relationship between lung function and cognitive functioning remains unknown. Results of existing studies concerning this relationship are inconsistent. Several studies suggest that physical activity is associated with the maintenance and improvement in cognitive function in COPD. Further studies are needed to explore this relationship. Understanding of the relationship between lung function, physical activity and cognitive functioning may help to prevent, to recognize and to develop optimal care programs for patients with impairment in lung function and cognitive impairment.
The aims of this study are: 1) to compare cognitive functioning between patients with and without COPD; 2) to analyze the relationship between severity of impairment in lung function and severity of cognitive impairment; and 3) to study the relationship between cognitive functioning and the level of physical activity in persons with and without COPD.
Cleutjens FAHM, Spruit MA, Ponds RWHM, Dijkstra JB, Franssen FME and Wouters EFM (2014) Cognitive Functioning in Obstructive Lung Disease: Results from the United Kingdom Biobank, Journal of the American Medical Directors Association 15(3), March 2014, 214-219.
|Lead investigator:||Dr. Daisy Janssen|