WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
This study will identify the world's largest group of subjects with RF/ACPA before the diagnosis of RA. Identifying those factors that are related to the development of RF/ACPA in the blood at first, and then the subsequent development of full blown RA will give insights into the cause of RA.
Siebert S, Lyall DM, Mackay DF, et al. Characteristics of rheumatoid arthritis and its association with major comorbid conditions: cross-sectional study of 502 649 UK Biobank participants. RMD Open 2016;2:e000267. doi:10.1136/rmdopen-2016-000267
Study to identify risk factors for RA, osteoporosis and cardiovascular disease
Rheumatoid Arthritis (RA) is a common type of arthritis, affecting >600,000 people in the UK. It can cause pain, stiffness and disability. People with RA may also develop other illnesses, such as heart disease or osteoporosis (thinning of the bones). Some people are more prone to develop RA because of their genes, but other lifestyle factors such as smoking are also important. As a result of their genes and exposure to these other factors, some people develop antibodies in their blood stream, called rheumatoid factor (RF) or anti-citrullinated protein antibodies (ACPA).