Visual Impairment: For the 65,033 UK Biobank participants, aged 40-69, with enhanced eye assessments, 6,682 (10.3%) and 1,677 (2.6%) had mild visual impairment or worse in one or both eyes respectively. The prevalence of visual impairment in the UK Biobank study cohort is lower than for population-based studies from other industrialised countries. Increasing Townsend deprivation score, age and ethnicity were independently associated with both monocular and binocular visual impairment. The most common identifiable diagnoses leading to monocular visual impairment were cataract, amblyopia, uncorrected refractive error (URE) and vitreo-retinal interface abnormalities (VRIA). The most common diagnoses leading to visual impairment in the better-seeing eyes of those with binocular visual impairment were URE, cataract and VRIA. No primary diagnosis for the recorded level of visual impairment could be identified for 49.8% of eyes. The UK Biobank dataset may therefore be inadequate to identify the causes of visual impairment with confidence.
The causes of and risk factors for visual impairment in middle-aged adults in the UK Biobank
The aim of this study was to determine the prevalence of vitreoretinal interface abnormalities (VRIA), the degree of visual impairment and associations with VRIA among adults, aged 40 69 years, in the UK Biobank study.
In this study with UK Biobank participants, VRIA were common abnormalities, both in eyes with and without visual impairment, and were identified at least four times more often with spectral domain optical coherence tomography (OCT) imaging than with colour fundus photography.
Visual impairment due to VRIA was typically mild or moderate and the most common VRIA were epiretinal membrane and vitreomacular traction. Visual impairment in one or both eyes and a VRIA was positively associated with increasing age, female gender and Asian or Asian British ethnicity.
To cite: McKibbin M, Farragher T, Shickle D. Vitreoretinal interface abnormalities in middle-aged adults with visual impairment in the UK Biobank study: prevalence, impact on visual acuity and associations. BMJ Open Ophth 2017;0:e000057. doi:10.1136/ bmjophth-2016-000057
|Lead investigator:||Martin McKibbin|
|Lead institution:||Leeds Teaching Hospitals NHS Trust|