| Application: | 7155, Epidemiology of mental health, cognitive function, pain and cardiometabolic disease. |
| Title: | Vitamin D concentrations and COVID-19 infection in UK Biobank |
| Size: | 3302 B |
| Archived: | 27 Jul 2021 |
| Stability: | Complete |
| Personal: | No individual-level data |
Return 3674
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Notes
Background and aimsCOVID-19 and low levels of vitamin D appear to disproportionately affect black and minority ethnic individuals. We aimed to establish whether blood 25-hydroxyvitamin D (25(OH)D) concentration was associated with COVID-19 risk, and whether it explained the higher incidence of COVID-19 in black and South Asian people.
Methods
UK Biobank recruited 502,624 participants aged 37-73 years between 2006 and 2010. Baseline exposure data, including 25(OH)D concentration and ethnicity, were linked to COVID-19 test results. Univariable and multivariable logistic regression analyses were performed for the association between 25(OH)D and confirmed COVID-19, and the association between ethnicity and both 25(OH)D and COVID-19.
Results
Complete data were available for 348,598 UK Biobank participants. Of these, 449 had confirmed COVID-19 infection. Vitamin D was associated with COVID-19 infection univariably (OR = 0.99; 95% CI 0.99-0.999; p = 0.013), but not after adjustment for confounders (OR = 1.00; 95% CI = 0.998-1.01; p = 0.208). Ethnicity was associated with COVID-19 infection univariably (blacks versus whites OR = 5.32, 95% CI = 3.68-7.70, p-value<0.001; South Asians versus whites OR = 2.65, 95% CI = 1.65-4.25, p-value<0.001). Adjustment for 25(OH)D concentration made little difference to the magnitude of the association.
Conclusions
Our findings do not support a potential link between vitamin D concentrations and risk of COVID-19 infection, nor that vitamin D concentration may explain ethnic differences in COVID-19 infection.
Application 7155
Epidemiology of mental health, cognitive function, pain and cardiometabolic disease.
Mental health problems place a large burden on the health service. As life expectancy increases, understanding cognitive decline is increasingly important. Identifying high risk groups enables us to detect problems early and target resources. Understanding the distribution of disease between groups can help elucidate the causes of disease and help identify new methods of prevention and treatment. Aim: To study the epidemiology of mental health, cognitive function, pain and cardiometabolic disease. Objectives: To examine the frequency, distribution, determinants and outcomes of these conditions, in relation to: demographics, lifestyle, comorbidity and medication UKB is representative of the general population in terms of age, sex and ethnicity but unrepresentative in terms of lifestyle. Therefore, it is not suitable to determine the overall prevalence of any condition but can, nonetheless, be used to compare the distribution of diseases between sub-groups and therefore determine associations between risk factors and disease frequency and outcome. This project builds on our ongoing study (774) which examines ethnic differences in cardiometabolic disease. We seek to extend the focus to examine other determinants of cardiometabolic disease as well as determinants of mood disorder, cognitive impairment and pain. We will compare participants with and without mood disorder, pain, cognitive impairment and cardiometabolic diease and participants with varying severity of these conditions in relation to a series of demographic and lifestyle factors in order to determine the factors associated with the conditions. We will also examine the association between these conditions and other diseases. The findings will help to identify individual at increased risk and modifiable factors that may help to prevent or alleviate these conditions. all participants
| Lead investigator: | Professor Jill Pell |
| Lead institution: | University of Glasgow |
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| 3675 | 7155 | Vitamin D and COVID-19 infection and mortality in UK Biobank | 27 Jul 2021 |
1 Publication
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 3675 | Vitamin D concentrations and COVID-19 infection in UK Biobank | Claire E Hastie (+13) | 2020 | Diabetes & Metabolic Syndrome Clinical Research & Reviews |
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