| Title: | Alcohol consumption and accelerated biological ageing in middle-aged and older people: A longitudinal study from two cohorts |
| Journal: | Addiction |
| Published: | 28 Apr 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/38679855/ |
| DOI: | https://doi.org/10.1111/add.16501 |
Publication 9794
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Abstract
BACKGROUND AND AIMS: The relationship between alcohol consumption and age-related diseases is inconsistent. Biological age (BA) serves as both a precursor and a predictor of age-related diseases; however, longitudinal associations between alcohol consumption and BA in middle-aged and older people remain unclear. We measured whether there was a longitudinal association between drinking frequency and pure alcohol intake with BA among middle-aged and older people.</p>
DESIGN AND SETTING AND PARTICIPANTS: This study involved two prospective cohort studies, set in Southwestern China and the United Kingdom. A total of 8046 participants from the China Multi-Ethnic Cohort study (CMEC) and 5412 participants from the UK Biobank (UKB), aged 30-79 years, took part, with complete data from two waves of clinical biomarkers.</p>
MEASUREMENTS: BA was calculated by the Klemera Doubal's method. Accelerated BA equalled BA minus chronological age. Drinking frequency and pure alcohol intake were obtained through self-reported questionnaires. Drinking frequency in the past year was classified as current non-drinking, occasional (monthly drinking) and regular (weekly drinking).</p>
FINDINGS: Compared with consistent current non-drinkers, more frequent drinkers [CMEC: β = 0.46, 95% confidence interval (CI) = 0.13-0.80; UKB: β = 0.65, 95% CI = 0.01-1.29)], less frequent drinkers (CMEC: β = 0.62, 95% CI = 0.37-0.87; UKB: β = 0.54, 95% CI = -0.01-1.09), consistent occasional drinkers (CMEC: β = 0.51, 95% CI = 0.23-0.79; UKB: β = 0.63, 95% CI = 0.13-1.13) and consistent regular drinkers (CMEC: β = 0.56, 95% CI = 0.17-0.95; UKB: β = 0.46, 95% CI = 0.00-0.91) exhibited increased accelerated BA. A non-linear relationship between pure alcohol intake and accelerated BA was observed among consistent regular drinkers.</p>
CONCLUSIONS: In middle-aged and older people, any change in drinking frequency and any amount of pure alcohol intake seem to be positively associated with acceleration of biological ageing, compared with maintaining abstinence.</p>
13 Authors
- Hongxiang Chen
- Jianzhong Yin
- Yi Xiang
- Ning Zhang
- Zitong Huang
- Yuan Zhang
- Dan Tang
- Ziyun Wang
- Baimayangji
- Liling Chen
- Xiaoman Jiang
- Xiong Xiao
- Xing Zhao
1 Application
| Application ID | Title |
|---|---|
| 117185 | Research on risk factors and pathogenesis of aging-related chronic diseases |
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