| Title: | FEV1 and FVC as robust risk factors for cardiovascular disease and mortality: Insights from a large population study |
| Journal: | Respiratory Medicine |
| Published: | 25 Apr 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/38670319/ |
| DOI: | https://doi.org/10.1016/j.rmed.2024.107614 |
| URL: | http://www.resmedjournal.com/article/S095461112400088X/pdf |
Publication 9833
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Abstract
INTRODUCTION: Data is limited on influence of forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC) in a large adult population, including individuals with normal spirometry at baseline.</p>
METHODS: Using the UK Biobank cohort, a multivariable Cox regression analysis was conducted on 406,424 individuals to examine the association between FEV1 and FVC, categorized into three groups based on their percentage of predicted values (%pred) (≥80, 60-80 and < 60), and overall mortality, cardiovascular mortality, myocardial infarction, stroke, and heart failure over approximately 12.5 years. Moreover, a subgroup analysis was conducted on 295,459 individuals who had normal spirometry.</p>
RESULTS: Reduced FEV1 and FVC %pred values were associated with an elevated risk across all studied outcomes. Individuals with the lowest FEV1 and FVC %pred values (<60 %) exhibited HR of 1.83 (95 % CI 1.74-1.93) and 1.98 (95 % CI 1.76-2.22) for overall mortality, and 1.96 (95 % CI 1.83-2.1) and 2.26 (95 % CI 1.94-2.63) for cardiovascular mortality. Moreover, a graded association was observed between lower FEV1 and FVC %pred, even among never smokers and individuals with normal spirometry at baseline.</p>
DISCUSSION: Reduced FEV1 and FVC represent robust risk factors for cardiovascular disease and mortality. The fact that the increased risk was evident also at FEV1 and FVC levels exceeding 80 %pred challenges the contemporary classification of lung function categories and the notion that the entire FEV1- and FVC-range above 80 % of predicted represents a normal lung function.</p>
5 Authors
- Andreas Rydell
- Christer Janson
- Karin Lisspers
- Yi-Ting Lin
- Johan Ärnlöv
1 Application
| Application ID | Title |
|---|---|
| 81508 | The role of lifestyle including physical activity, pain, -omics biomarkers and genetics in cardiovascular disease and kidney function |
Enabling scientific discoveries that improve human health