Background: Prostate cancer is the most common cancer in British men but its aetiology is not well understood. We aimed to identify risk factors for prostate cancer in British males.
Methods: We studied 219 335 men from the UK Biobank study who were free from cancer at baseline. Exposure data were collected at recruitment. Prostate cancer risk by the different exposures was estimated using multivariable-adjusted Coxproportional hazards models.
Results: In all, 4575 incident cases of prostate cancer occurred during 5.6 years of follow-up. Prostate cancer risk was positively associated with the following: black ethnicity (hazard ratio black vs white = 2.61, 95% confidence interval = 2.10 3.24); having ever had a prostate-specific antigen test (1.31, 1.23 1.40); being diagnosed with an enlarged prostate (1.54, 1.38 1.71); and having a family history of prostate cancer (1.94, 1.77 2.13). Conversely, Asian ethnicity (Asian vs white hazard ratio = 0.62, 0.47 0.83), excess adiposity (body mass index (>=35 vs <25 kg/m2 = 0.75, 0.64 0.88) and body fat (>=30.1 vs <20.5% = 0.81, 0.73 0.89)), cigarette smoking (current vs never smokers = 0.85, 0.77 0.95), having diabetes (0.70, 0.62 0.80), and never having had children (0.89, 0.81 0.97) or sexual intercourse (0.53, 0.33 0.84) were related to a lower risk.
Conclusions: In this new large British prospective study, we identified associations with already-established, putative and possible novel risk factors for being diagnosed with prostate cancer. Future research will examine associations by tumour characteristics.
Prostate Cancer Epidemiology Consortium: Risk factors for prostate cancer
Prostate Cancer Epidemiology Consortium
We propose a research programme on hormonal, anthropometric, dietary and lifestyle factors and prostate cancer risk; this will extend the work of an existing consortium co-ordinated in the Cancer Epidemiology Unit Oxford, the Endogenous Hormones, Nutritional Biomarkers and Prostate Cancer Collaborative Group. Initially we will describe the distributions of potential prostate cancer risk factors for men in UK Biobank (including personal characteristics, anthropometry, diet, alcohol intake, physical activity and history of use of the prostate-specific antigen (PSA) blood test). This will provide information that will help in the planning of further analyses of prostate cancer by users of Biobank. When at least 2000 cases of prostate cancer have accrued we will begin the main phase of the project, which is to examine the associations between prostate cancer risk and levels of blood biomarkers (including sex hormones, growth factors and nutritional biomarkers such as vitamin D) as well as personal characteristics and lifestyle factors, using a case-cohort design. This project will help us to understand what lifestyle factors are associated with risk and the mechanisms through which they may exert an effect.
|Lead investigator:||Dr Ruth Travis|
|Lead institution:||University of Oxford|
1 related Return
|Return ID||App ID||Description||Archive Date|
|529||3282||Lifestyle factors and prostate-specific antigen (PSA) testing in UK Biobank: Implications for epidemiological research||5 Jun 2017|
|2169||Prospective investigation of risk factors for prostate cancer in the UK Biobank cohort study||Perez-Cornago A et al.||2017||Br J Cancer|