| Application: | 408, Derivation of fitness indicators and their relation with hemodynamic factors |
| Title: | Cardiorespiratory fitness assessment using risk-stratified exercise testing and dose-response relationships with disease outcomes |
| Size: | 8.3 MB |
| Archived: | 30 Oct 2023 |
| Stability: | Complete |
| Personal: | Contains individual-level data |
Return 2221
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Notes
This return contains participant-level cardiorespiratory fitness estimates from the UK biobank bike test. The method we used to estimate fitness from the test was validated against direct measurements of fitness in an independent study, demonstrating acceptable agreement.Application 408
Derivation of fitness indicators and their relation with hemodynamic factors
Few large-scale epidemiological studies have included measures of cardio-respiratory fitness, but those that have indicate that it is strongly related to metabolic disease, cardiovascular outcomes, some cancers, and all-cause mortality. Some recent estimates from Health Survey for England (2008) indicate mean levels of fitness to be around 32 and 36 ml O2/min/kg for adult women and men, respectively. It is generally agreed, however, that this represents an overestimate due to stringent exclusion criteria (>40%). The exercise test used in UK Biobank was designed to be as inclusive as possible to maximise the potential for linkage with incident disease. More specifically, exercise protocols were individualised to take into account participant characteristics including risk category. This proposal aims to derive fitness indicators from information collected during the exercise test, and describe their variation by appropriate subgroups. Finally, we aim to demonstrate the etiological utility of derived fitness measures by examining the cross-sectional association with blood pressure and arterial stiffness.
| Lead investigator: | Dr Soren Brage |
| Lead institution: | University of Cambridge |
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