| Application: | 17689, Genetic, environmental and lifestyle predictors of brain/cognitive-related outcomes. |
| Title: | Assessing for interaction between APOE e4, sex, and lifestyle on cognitive abilities |
| Size: | 1.1 MB |
| Archived: | 30 Oct 2020 |
| Stability: | Complete |
| Personal: | No individual-level data |
Return 2704
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Notes
APOE e4 genotype is found in about 25% of the general population. It is a known risk factor for dementia.It has sometimes been called the 'frailty gene', partly because it seems to increase vulnerability to thinks like brain injury.
We asked: do people with e4 genotype (vs. protective e2 or neutral e3) show a larger negative association with other known risk factors for worse brain health, like smoking, alcohol intake and sedentary behaviour?
We asked this in terms of cognitive abilities like memory, reasoning and reaction time.
The answer seemed to be no: the association between e4 genotype and cognitive ability scores was signfificant, but did not seem to interact with lifestyle.
The implication here is that if you do have the e4 'risk' genotype, the role of lifestyle is not more or less important than normal.
Application 17689
Genetic, environmental and lifestyle predictors of brain/cognitive-related outcomes.
The project aims to integrate genetic, biomarker, brain imaging and cognitive/mood data to give a complete 'picture' of what predicts, mediates and moderates worse mental ability and mood disorder in UK Biobank, cross-sectionally and prospectively using follow-up data. We will research this question using UK Biobank cognitive test, brain MRI (structural and functional), biomarker (i.e. assay), mood-related and cognitive data, using formal tests of association, mediation and moderation. We will use the primary care and HES data in order to ascertain follow-up mood disorders. Our project meets UK Biobank?s stated purpose of improving the prevention, diagnosis and treatment of illnesses by identifying risk factors for lower cognitive ability and mood disorder; important risk factors for physical ill health, earlier mortality and lower quality of life. Insights from this work will lead to a better understanding of disease processes in cognitive decline and Alzheimer's disease (dementia) and mood disorders such as depression, including better approaches to diagnosis and ultimately the development of new treatments. The work will consist of using genome-wide association (GWA) data in the UK Biobank, together with environmental variables e.g. sociodemographics, and lifestyle variables e.g. health related behaviours like smoking status, alcohol intake etc., to test for independent associations with cognitive abilities and mood disorders, both at baseline and at follow-up, based on NHS record linkage. We will test for how these associations are mediated by brain MRI variables, and/or moderated by biomarker variables (e.g. lipid levels, inflammatory markers). The project will make full use of phenotypic, genetic, raw/derived brain MRI/fMRI and biomarker data in the full cohort (as and when each aspect becomes available).
| Lead investigator: | Dr Donald Lyall |
| Lead institution: | University of Glasgow |
6 related Returns
| Return ID | App ID | Description | Archive Date |
|---|---|---|---|
| 3402 | 17689 | Alzheimer's Disease Susceptibility Gene Apolipoprotein E (APOE) and Blood Biomarkers in UK Biobank (N = 395,769) | 11 May 2021 |
| 2728 | 17689 | Association between APOE e4 and white matter hyperintensity volume, but not total brain volume or white matter integrity | 2 Nov 2020 |
| 3403 | 17689 | Association of systolic blood pressure and body mass index with cognitive and structural brain phenotypes in UK Biobank | 11 May 2021 |
| 3404 | 17689 | PCSK9 genetic variants and cognitive abilities: a large-scale Mendelian randomization study | 11 May 2021 |
| 2729 | 17689 | Social engagement after stroke - is it relevant to cognitive function? A cross-sectional analysis of UK Biobank data | 2 Nov 2020 |
| 2590 | 17689 | The associations between self-reported depression, self-reported chronic inflammatory conditions and cognitive abilities in UK Biobank | 27 Oct 2020 |
1 Publication
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 2705 | Assessing for interaction between APOE ε4, sex, and lifestyle on cognitive abilities | Lyall DM et al. | 2019 | Neurology |
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