| Application: | 23183, Dietary iron intake and public health risk |
| Title: | Muscle mass measures and incident osteoporosis in a large cohort of postmenopausal women |
| Size: | 236399 B |
| Archived: | 5 Nov 2020 |
| Stability: | Complete |
| Personal: | No individual-level data |
Return 2806
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Notes
Despite several muscle mass measures being used in the current definitions of sarcopenia, their usefulness is uncertain because of limited data on their association with health outcomes. This study compared the performance of different muscle mass measures in predicting incident osteoporosis in 149,166 postmenopausal women (mean age 60.3 years). The muscle mass measures included were total body skeletal muscle mass (SMM) and appendicular SMM (aSMM) divided by height squared (ht^2), derived residuals, SMM, SMM adjusted for body mass (SMM/bm 100), and aSMM normalized for body mass index (aSMM/BMI). It was found that muscle mass measures adjusted for height only (SMM/ht^2, aSMM/ht^2) appear to be better muscle-relevant risk factors for incident osteoporosis in postmenopausal women, including when stratified into lean participants and participants with increased adiposity.Application 23183
Dietary iron intake and public health risk
We aim to investigate the relationship between dietary iron intake on a broad range of health outcomes. General research questions include: 1. Does high iron intake relate to chronic disease outcomes such as cancer, cardiovascular disease, diabetes, alterations in cardiovascular structure and function and the metabolic syndrome? 2. Do interactions exist between dietary iron intake and measures of lifestyle (e.g. smoking, alcohol consumption, obesity) and does it predict the above outcomes? 3. Are consumers of heme iron sources at higher disease risk than non-heme iron consumers? Iron is an essential trace element for the human body, although it can also be toxic due to oxidative stress generation. Even mild cases of iron overload increases the risk for liver disease, cardiovascular disease, diabetes, osteoporosis, and metabolic syndrome. In the Framingham Heart Study, only 3 percent had deficient iron levels, but 13 percent had levels considered too high suggesting too high rather than too low (as believed) iron intake in the general population. The proposed research aims to reduce scientific uncertainty and improve the evidence base to guide UK public health policy regarding dietary iron intake. We will examine the relationship between dietary iron intake and various measures of health, including cancer, cardiovascular disease, osteoporosis, diabetes, alterations in cardiovascular structure and function and the metabolic syndrome, whilst taking into account covariates and potential confounders. As an unhealthy lifestyle adversely affects the intestinal barrier increasing iron absorption, we will investigate whether there is predictive value of potential interactions between dietary iron intake and measures of lifestyle such as smoking, alcohol use and obesity. Lastly, we will determine whether high heme-iron consumers are at higher disease risk compared to low heme-iron consumers. The research will include the full cohort for which information on dietary iron is available, i.e., 211,063.
| Lead investigator: | Dr Rudolph Schutte |
| Lead institution: | Anglia Ruskin University |
1 Publication
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 2807 | Muscle mass measures and incident osteoporosis in a large cohort of postmenopausal women | Papageorgiou M et al. | 2019 | J Cachexia Sarcopenia Muscle |
Enabling scientific discoveries that improve human health