| Application: | 6553, Genome-wide association studies of mental health. |
| Title: | The genomic basis of mood instability: identification of 46 loci in 363,705 UK Biobank participants, genetic correlation with psychiatric disorders, and association with gene expression and function |
| Size: | 701002 B |
| Archived: | 29 Sep 2021 |
| Stability: | Complete |
| Personal: | No individual-level data |
Return 3888
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Notes
We performed a genome-wide association study of mood instability and performed genetic correlations with 5 psychiatric pathologies. We identified 46 regions of the genome that associated with mood instability and all the genetic correlations showed a positive correlation. We also used the summary statistics to perform a phenotype linkage network analysis which allowed us to identify gene clusters containing melatonin receptors.Application 6553
Genome-wide association studies of mental health.
The primary aim of this research is to identify genetic associations with a) major depression plus mania/bipolar disorder, and b) vulnerability to depression and other negative mood states (as measured by neuroticism score). These aims will be achieved by conducting genome-wide association studies (GWAS), making use of data from the UK Biobank genotyping project. This project is linked to previous analyses our team have undertaken on Biobank data in the areas of mood disorder, cognitive function, cardiometabolic disease and ethnicity and meets Biobank?s stated purpose of improving the prevention, diagnosis and treatment of illnesses by identifying genetic risk factors for common mental disorders, as well as genetic risk factors for trait-like vulnerability to these disorders (neuroticism). Insights from this work will lead to a better understanding of disease processes in depression, better approaches to diagnosis and ultimately the development of new treatments. This work will consist of genome-wide association studies (GWAS), making use of data from the UK Biobank genotyping project. These GWAS studies on depression and neuroticism will make use of phenotypic and genetic data on all Biobank participants (full cohort).
| Lead investigator: | Dr Rona Strawbridge |
| Lead institution: | University of Glasgow |
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