| Title: | Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals |
| Journal: | Communications Biology |
| Published: | 13 Jun 2022 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/35697829/ |
| DOI: | https://doi.org/10.1038/s42003-022-03448-z |
| URL: | https://www.nature.com/articles/s42003-022-03448-z.pdf |
Publication 10329
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Abstract
Reduced glomerular filtration rate (GFR) can progress to kidney failure. Risk factors include genetics and diabetes mellitus (DM), but little is known about their interaction. We conducted genome-wide association meta-analyses for estimated GFR based on serum creatinine (eGFR), separately for individuals with or without DM (nDM = 178,691, nnoDM = 1,296,113). Our genome-wide searches identified (i) seven eGFR loci with significant DM/noDM-difference, (ii) four additional novel loci with suggestive difference and (iii) 28 further novel loci (including CUBN) by allowing for potential difference. GWAS on eGFR among DM individuals identified 2 known and 27 potentially responsible loci for diabetic kidney disease. Gene prioritization highlighted 18 genes that may inform reno-protective drug development. We highlight the existence of DM-only and noDM-only effects, which can inform about the target group, if respective genes are advanced as drug targets. Largely shared effects suggest that most drug interventions to alter eGFR should be effective in DM and noDM.</p>
314 Authors
- Thomas W. Winkler
- Humaira Rasheed
- Alexander Teumer
- Mathias Gorski
- Bryce X. Rowan
- Kira J. Stanzick
- Laurent F. Thomas
- Adrienne Tin
- Anselm Hoppmann
- Audrey Y. Chu
- Bamidele Tayo
- Chris H. L. Thio
- Daniele Cusi
- Jin-Fang Chai
- Karsten B. Sieber
- Katrin Horn
- Man Li
- Markus Scholz
- Massimiliano Cocca
- Matthias Wuttke
- Peter J. van der Most
- Qiong Yang
- Sahar Ghasemi
- Teresa Nutile
- Yong Li
- Giulia Pontali
- Felix Günther
- Abbas Dehghan
- Adolfo Correa
- Afshin Parsa
- Agnese Feresin
- Aiko P. J. de Vries
- Alan B. Zonderman
- Albert V. Smith
- Albertine J. Oldehinkel
- Alessandro De Grandi
- Alexander R. Rosenkranz
- Andre Franke
- Andrej Teren
- Andres Metspalu
- Andrew A. Hicks
- Andrew P. Morris
- Anke Tönjes
- Anna Morgan
- Anna I. Podgornaia
- Annette Peters
- Antje Körner
- Anubha Mahajan
- Archie Campbell
- Barry I. Freedman
- Beatrice Spedicati
- Belen Ponte
- Ben Schöttker
- Ben Brumpton
- Bernhard Banas
- Bernhard K. Krämer
- Bettina Jung
- Bjørn Olav Åsvold
- Blair H. Smith
- Boting Ning
- Brenda W. J. H. Penninx
- Brett R. Vanderwerff
- Bruce M. Psaty
- Candace M. Kammerer
- Carl D. Langefeld
- Caroline Hayward
- Cassandra N. Spracklen
- Cassianne Robinson-Cohen
- Catharina A. Hartman
- Cecilia M. Lindgren
- Chaolong Wang
- Charumathi Sabanayagam
- Chew-Kiat Heng
- Chiara Lanzani
- Chiea-Chuen Khor
- Ching-Yu Cheng
- Christian Fuchsberger
- Christian Gieger
- Christian M. Shaffer
- Christina-Alexandra Schulz
- Cristen J. Willer
- Daniel I. Chasman
- Daniel F. Gudbjartsson
- Daniela Ruggiero
- Daniela Toniolo
- Darina Czamara
- David J. Porteous
- Dawn M. Waterworth
- Deborah Mascalzoni
- Dennis O. Mook-Kanamori
- Dermot F. Reilly
- E. Warwick Daw
- Edith Hofer
- Eric Boerwinkle
- Erika Salvi
- Erwin P. Bottinger
- E-Shyong Tai
- Eulalia Catamo
- Federica Rizzi
- Feng Guo
- Fernando Rivadeneira
- Franco Guilianini
- Gardar Sveinbjornsson
- Georg Ehret
- Gerard Waeber
- Ginevra Biino
- Giorgia Girotto
- Giorgio Pistis
- Girish N. Nadkarni
- Graciela E. Delgado
- Grant W. Montgomery
- Harold Snieder
- Harry Campbell
- Harvey D. White
- He Gao
- Heather M. Stringham
- Helena Schmidt
- Hengtong Li
- Hermann Brenner
- Hilma Holm
- Holgen Kirsten
- Holly Kramer
- Igor Rudan
- Ilja M. Nolte
- Ioanna Tzoulaki
- Isleifur Olafsson
- Jade Martins
- James P. Cook
- James F. Wilson
- Jan Halbritter
- Janine F. Felix
- Jasmin Divers
- Jaspal S. Kooner
- Jeannette Jen-Mai Lee
- Jeffrey O'Connell
- Jerome I. Rotter
- Jianjun Liu
- Jie Xu
- Joachim Thiery
- Johan Ärnlöv
- Johanna Kuusisto
- Johanna Jakobsdottir
- Johanne Tremblay
- John C. Chambers
- John B. Whitfield
- John M. Gaziano
- Jonathan Marten
- Josef Coresh
- Jost B. Jonas
- Josyf C. Mychaleckyj
- Kaare Christensen
- Kai-Uwe Eckardt
- Karen L. Mohlke
- Karlhans Endlich
- Katalin Dittrich
- Kathleen A. Ryan
- Kenneth M. Rice
- Kent D. Taylor
- Kevin Ho
- Kjell Nikus
- Koichi Matsuda
- Konstantin Strauch
- Kozeta Miliku
- Kristian Hveem
- Lars Lind
- Lars Wallentin
- Laura M. Yerges-Armstrong
- Laura M. Raffield
- Lawrence S. Phillips
- Lenore J. Launer
- Leo-Pekka Lyytikäinen
- Leslie A. Lange
- Lorena Citterio
- Lucija Klaric
- M. Arfan Ikram
- Marcus Ising
- Marcus E. Kleber
- Margherita Francescatto
- Maria Pina Concas
- Marina Ciullo
- Mario Piratsu
- Marju Orho-Melander
- Markku Laakso
- Markus Loeffler
- Markus Perola
- Martin H. de Borst
- Martin Gögele
- Martina La Bianca
- Mary Ann Lukas
- Mary F. Feitosa
- Mary L. Biggs
- Mary K. Wojczynski
- Maryam Kavousi
- Masahiro Kanai
- Masato Akiyama
- Masayuki Yasuda
- Matthias Nauck
- Melanie Waldenberger
- Miao-Li Chee
- Miao-Ling Chee
- Michael Boehnke
- Michael H. Preuss
- Michael Stumvoll
- Michael A. Province
- Michele K. Evans
- Michelle L. O'Donoghue
- Michiaki Kubo
- Mika Kähönen
- Mika Kastarinen
- Mike A. Nalls
- Mikko Kuokkanen
- Mohsen Ghanbari
- Murielle Bochud
- Navya Shilpa Josyula
- Nicholas G. Martin
- Nicholas Y. Q. Tan
- Nicholette D. Palmer
- Nicola Pirastu
- Nicole Schupf
- Niek Verweij
- Nina Hutri-Kähönen
- Nina Mononen
- Nisha Bansal
- Olivier Devuyst
- Olle Melander
- Olli T. Raitakari
- Ozren Polasek
- Paolo Manunta
- Paolo Gasparini
- Pashupati P. Mishra
- Patrick Sulem
- Patrik K. E. Magnusson
- Paul Elliott
- Paul M. Ridker
- Pavel Hamet
- Per O. Svensson
- Peter K. Joshi
- Peter Kovacs
- Peter P. Pramstaller
- Peter Rossing
- Peter Vollenweider
- Pim van der Harst
- Rajkumar Dorajoo
- Ralene Z. H. Sim
- Ralph Burkhardt
- Ran Tao
- Raymond Noordam
- Reedik Mägi
- Reinhold Schmidt
- Renée de Mutsert
- Rico Rueedi
- Rob M. van Dam
- Robert J. Carroll
- Ron T. Gansevoort
- Ruth J. F. Loos
- Sala Cinzia Felicita
- Sanaz Sedaghat
- Sandosh Padmanabhan
- Sandra Freitag-Wolf
- Sarah A. Pendergrass
- Sarah E. Graham
- Scott D. Gordon
- Shih-Jen Hwang
- Shona M. Kerr
- Simona Vaccargiu
- Snehal B. Patil
- Stein Hallan
- Stephan J. L. Bakker
- Su-Chi Lim
- Susanne Lucae
- Suzanne Vogelezang
- Sven Bergmann
- Tanguy Corre
- Tarunveer S. Ahluwalia
- Terho Lehtimäki
- Thibaud S. Boutin
- Thomas Meitinger
- Tien-Yin Wong
- Tobias Bergler
- Ton J. Rabelink
- Tõnu Esko
- Toomas Haller
- Unnur Thorsteinsdottir
- Uwe Völker
- Valencia Hui Xian Foo
- Veikko Salomaa
- Veronique Vitart
- Vilmantas Giedraitis
- Vilmundur Gudnason
- Vincent W. V. Jaddoe
- Wei Huang
- Weihua Zhang
- Wen Bin Wei
- Wieland Kiess
- Winfried März
- Wolfgang Koenig
- Wolfgang Lieb
- Xin Gao
- Xueling Sim
- Ya Xing Wang
- Yechiel Friedlander
- Yih-Chung Tham
- Yoichiro Kamatani
- Yukinori Okada
- Yuri Milaneschi
- Zhi Yu
- Klaus J. Stark
- Kari Stefansson
- Carsten A. Böger
- Adriana M. Hung
- Florian Kronenberg
- Anna Köttgen
- Cristian Pattaro
- Iris M. Heid
1 Application
| Application ID | Title |
|---|---|
| 20272 | GWAS of kidney function related traits and kidney disease |
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