| Title: | Polygenic Risk Score and Risk Factors for Gestational Diabetes |
| Journal: | Journal of Personalized Medicine |
| Published: | 26 Aug 2022 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/36143166/ |
| DOI: | https://doi.org/10.3390/jpm12091381 |
| URL: | https://www.mdpi.com/2075-4426/12/9/1381/pdf?version=1661500765 |
Publication 10458
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Abstract
Gestational diabetes mellitus (GDM) is a common complication of pregnancy that adversely affects maternal and offspring health. A variety of risk factors, such as BMI and age, have been associated with increased risks of gestational diabetes. However, in many cases, gestational diabetes occurs in healthy nulliparous women with no obvious risk factors. Emerging data suggest that the tendency to develop gestational diabetes has genetic and environmental components. Here we develop a polygenic risk score for GDM and investigate relationships between its genetic architecture and genetically constructed risk factors and biomarkers. Our results demonstrate that the polygenic risk score can be used as an early screening tool that identifies women at higher risk of GDM before its onset allowing comprehensive monitoring and preventative programs to mitigate the risks.</p>
6 Authors
- Marija Majda Perišić
- Klemo Vladimir
- Sarah Karpov
- Mario Štorga
- Ali Mostashari
- Raya Khanin
1 Application
| Application ID | Title |
|---|---|
| 30281 | Study of the effect of genetic variants in vitamin and mineral metabolic pathways on health outcomes |
Enabling scientific discoveries that improve human health