| Title: | Associations of grip strength, walking pace, and the risk of incident dementia: A prospective cohort study of 340212 participants |
| Journal: | Alzheimer's & Dementia |
| Published: | 24 Sep 2022 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/36152312/ |
| DOI: | https://doi.org/10.1002/alz.12793 |
Publication 10474
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Abstract
INTRODUCTION: Grip strength and walking pace have been linked to cognitive dysfunction. Their relationships, however, demand further clarification as the evidence is derived primarily from less-comprehensive investigations.</p>
METHODS: A total of 340212 UK Biobank participants without dementia and cardiovascular diseases at baseline were analyzed. Cox proportional hazard models assessed the longitudinal associations.</p>
RESULTS: Over a mean follow-up of 8.51 ± 2.68 years, 2424 incident dementia cases were documented. A 5 kg increment of absolute grip strength was associated with lower risks of all-cause dementia (hazard ratio [HR] 0.857), Alzheimer's disease (HR 0.874), and vascular dementia (HR 0.788). The patterns of associations remained similar when grip strength was expressed in relative terms and quintiles. A slow walking pace demonstrated consistent associations with increased risks of all dementia types.</p>
DISCUSSION: Our findings provide amplified evidence and suggest that muscle fitness, reflected by objective grip strength measures and self-reported walking pace, may be imperative for estimating the risks of dementia.</p>
16 Authors
- Kevin Kuo
- Ya-Ru Zhang
- Shi-Dong Chen
- Xiao-Yu He
- Shu-Yi Huang
- Bang-Sheng Wu
- Yue-Ting Deng
- Liu Yang
- Ya-Nan Ou
- Yu Guo
- Rui-Qi Zhang
- Yi Zhang
- Lan Tan
- Qiang Dong
- Wei Cheng
- Jin-Tai Yu
1 Application
| Application ID | Title |
|---|---|
| 19542 | Identifying multi-level biomarkers and disease mechanisms for major mental disorders |
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