| Title: | Prediagnostic serum calcium concentrations and risk of colorectal cancer development in 2 large European prospective cohorts |
| Journal: | American Journal of Clinical Nutrition |
| Published: | 15 Dec 2022 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/36789942/ |
| DOI: | https://doi.org/10.1016/j.ajcnut.2022.10.004 |
Publication 10824
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Abstract
BACKGROUND: Higher dietary calcium consumption is associated with lower colorectal cancer (CRC) risk. However, little data are available on the association between circulating calcium concentrations and CRC risk.</p>
OBJECTIVES: To explore the association between circulating calcium concentrations and CRC risk using data from 2 large European prospective cohort studies.</p>
METHODS: Conditional logistic regression models were used to calculate multivariable-adjusted ORs and 95% CIs in case-control studies nested within the European Prospective Investigation into Cancer and Nutrition (EPIC; n-cases = 947, n-controls = 947) and the UK Biobank (UK-BB; n-cases = 2759, n-controls = 12,021) cohorts.</p>
RESULTS: In EPIC, nonalbumin-adjusted total serum calcium (a proxy of free calcium) was not associated with CRC (OR: 0.94; 95% CI: 0.85, 1.03; modeled as continuous variable, per 1 mg/dL increase), colon cancer (OR: 0.93; 95% CI: 0.82, 1.05) or rectal cancer (OR: 1.01; 95% CI: 0.84, 1.20) risk in the multivariable adjusted model. In the UK-BB, serum ionized calcium (free calcium, most active form) was inversely associated with the risk of CRC (OR: 0.85; 95% CI: 0.76, 0.95; per 1 mg/dL) and colon cancer (OR: 0.78; 95% CI: 0.68, 0.90), but not rectal cancer (OR: 1.02; 95% CI: 0.83, 1.24) in multivariable adjusted models. Meta-analysis of EPIC and UK-BB CRC risk estimates showed an inverse risk association for CRC in the multivariable adjusted model (OR: 0.90; 95%CI: 0.84, 0.97). In analyses by quintiles, in both cohorts, higher levels of serum calcium were associated with reduced CRC risk (EPIC: ORQ5vs.Q1: 0.69; 95% CI: 0.47, 1.00; P-trend = 0.03; UK-BB: ORQ5vs.Q1: 0.82; 95% CI: 0.72, 0.94; P-trend < 0.01). Analyses by anatomical subsite showed an inverse cancer risk association in the colon (EPIC: ORQ5vs.Q1: 0.63, 95% CI: 0.39, 1.02; P-trend = 0.05; UK-BB: ORQ5vs.Q1: 0.75; 95% CI: 0.64, 0.88; P-trend < 0.01) but not the rectum.</p>
CONCLUSIONS: In UK-BB, higher serum ionized calcium levels were inversely associated with CRC, but the risk was restricted to the colon. Total serum calcium showed a null association in EPIC. Additional prospective studies in other populations are needed to better investigate these associations.</p>
42 Authors
- Nena Karavasiloglou
- David J Hughes
- Neil Murphy
- Lutz Schomburg
- Qian Sun
- Vartiter Seher
- Sabine Rohrmann
- Elisabete Weiderpass
- Anne Tjønneland
- Anja Olsen
- Kim Overvad
- Marie-Christine Boutron-Ruault
- Francesca Romana Mancini
- Yahya Mahamat-Saleh
- Rudolf Kaaks
- Tilman Kuhn
- Matthias B Schulze
- Rosario Tumino
- Salvatore Panico
- Giovanna Masala
- Valeria Pala
- Carlotta Sacerdote
- Jeroen W G Derksen
- Guri Skeie
- Anette Hjartåker
- Cristina Lasheras
- Antonio Agudo
- Maria-José Sánchez
- Maria-Dolores Chirlaque
- Eva Ardanaz
- Pilar Amiano
- Bethany Van Guelpen
- Björn Gylling
- Kathryn E Bradbury
- Keren Papier
- Heinz Freisling
- Elom K Aglago
- Amanda J Cross
- Elio Riboli
- Dagfinn Aune
- Marc J Gunter
- Mazda Jenab
1 Application
| Application ID | Title |
|---|---|
| 25897 | An investigation of anthropometry, physical inactivity, metabolic syndrome and type-2 diabetes on colorectal cancer development. |
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