| Title: | Mapping of UK Biobank clinical codes: Challenges and possible solutions |
| Journal: | PLOS ONE |
| Published: | 16 Dec 2022 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/36525430/ |
| DOI: | https://doi.org/10.1371/journal.pone.0275816 |
| URL: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0275816&type=printable |
Publication 10830
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Abstract
OBJECTIVE: The UK Biobank provides a rich collection of longitudinal clinical data coming from different healthcare providers and sources in England, Wales, and Scotland. Although extremely valuable and available to a wide research community, the heterogeneous dataset contains inconsistent medical terminology that is either aligned to several ontologies within the same category or unprocessed. To make these data useful to a research community, data cleaning, curation, and standardization are needed. Significant efforts to perform data reformatting, mapping to any selected ontologies (such as SNOMED-CT) and harmonization are required from any data user to integrate UK Biobank hospital inpatient and self-reported data, data from various registers with primary care (GP) data. The integrated clinical data would provide a more comprehensive picture of one's medical history.</p>
MATERIALS AND METHODS: We evaluated several approaches to map GP clinical Read codes to International Classification of Diseases (ICD) and Systematized Nomenclature of Medicine Clinical Terms (SNOMED CT) terminologies. The results were compared, mapping inconsistencies were flagged, a quality category was assigned to each mapping to evaluate overall mapping quality.</p>
RESULTS: We propose a curation and data integration pipeline for harmonizing diagnosis. We also report challenges identified in mapping Read codes from UK Biobank GP tables to ICD and SNOMED CT.</p>
DISCUSSION AND CONCLUSION: Some of the challenges-the lack of precise one-to-one mapping between ontologies or the need for additional ontology to fully map terms-are general reflecting trade-offs to be made at different steps. Other challenges are due to automatic mapping and can be overcome by leveraging existing mappings, supplemented with automated and manual curation.</p>
11 Authors
- Oleg Stroganov
- Alena Fedarovich
- Emily Wong
- Yulia Skovpen
- Elena Pakhomova
- Ivan Grishagin
- Dzmitry Fedarovich
- Tania Khasanova
- David Merberg
- Sándor Szalma
- Julie Bryant
1 Application
| Application ID | Title |
|---|---|
| 26041 | Large-Scale Sequencing in the UK Biobank to Facilitate Gene Discovery, Genome Sciences, and Precision Medicine |
Enabling scientific discoveries that improve human health