| Title: | Associations of serum uric acid levels with liver disease-related morbidity and mortality: A prospective cohort study of the UK Biobank |
| Journal: | Liver International |
| Published: | 29 Mar 2023 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/36938749/ |
| DOI: | https://doi.org/10.1111/liv.15564 |
Publication 11259
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Abstract
BACKGROUND AND AIMS: The association of serum uric acid (SUA) levels with liver-related morbidity and mortality remains undetermined. Therefore, we aimed to explore the association of SUA levels with liver-related morbidity and mortality.</p>
METHODS: The present cohort study included 459 619 adults from the UK Biobank. Multivariable Cox proportional hazards models were used to estimate the hazard ratios (HRs) and 95% confidence intervals (CIs) for the associations of SUA levels with morbidity and mortality of overall liver disease. Mendelian randomization (MR) analyses were conducted to explore the underlying causality. A polygenic risk score was generated to assess whether there was a gene-exposure interaction.</p>
RESULTS: During a median follow-up of 12.6 years, 14 302 nonfatal and 609 fatal cases of overall liver disease were identified. Compared to individuals in the lowest quartile, the HRs (95% CI) of incident overall liver disease were 1.08 (1.02-1.14), 1.13 (1.07-1.20) and 1.44 (1.36-1.53) for individuals with SUA levels in quartiles 2, 3 and 4 respectively. Similarly, the HRs (95% CI) of liver disease-associated mortality were 1.09 (0.78-1.52), 1.55 (1.14-2.13) and 1.96 (1.42-2.69) for individuals with SUA levels in quartiles 2, 3 and 4 respectively. The MR results did not support the causal association of SUA levels with liver disease. In addition, there was a significant modification effect of the polygenic risk score on the association of SUA levels with incident overall liver disease (pinteraction = .003).</p>
CONCLUSIONS: Higher SUA levels were significantly associated with an increased risk of overall liver disease morbidity and mortality.</p>
4 Authors
- Zhening Liu
- Hangkai Huang
- Jiarong Xie
- Chengfu Xu
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