: Publication 11392

Publication 11392

Title:	Dose-Response Associations of Dietary Inflammatory Potential With Health Outcomes: A Prospective Cohort Study of 198,265 UK Biobank Participants
Journal:	Current Problems in Cardiology
Published:	29 Apr 2023
Pubmed:	https://pubmed.ncbi.nlm.nih.gov/37121456/
DOI:	https://doi.org/10.1016/j.cpcardiol.2023.101774

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Abstract

To investigate the dose-response associations of dietary inflammatory potential with all-cause mortality and incident cardiovascular disease (CVD) and cancer.</p>

METHODS: This was a prospective cohort study of 198,265 UK Biobank participants who completed at least 1 dietary assessment. A web based 24 hours recall questionnaire was used to derive the energy-adjusted dietary inflammatory index (E-DII). All-cause mortality and incident CVD and cancer ascertained from linked records.</p>

RESULTS: After adjusting for socio-demographic and lifestyle factors, there were J-shaped associations of E-DII with all-cause mortality and CVD, and a relatively linear association with cancer. When E-DII was <0, E-DII was not associated with any of the outcomes. When E-DII was ≥0, the linear associations were strongest in all-cause mortality (HR 1.09, 95% CI, 1.05-1.13), followed by CVD (HR 1.06, 95% CI, 1.03-1.09), and cancer (HR 1.03, 95%,CI, 1.01-1.05).</p>

CONCLUSION: Dietary inflammatory potential was associated with mortality and CVD primarily when the diet is proinflammatory.</p>

12 Authors

Frederick K Ho
Michael D Wirth
Solange Parra-Soto
Jirapitcha Boonpor
Ziyi Zhou
Fanny Petermann-Rocha
Shinya Nakada
Katherine M Livingstone
John C Mathers
Jill P Pell
James R Hébert
Carlos Celis-Morales

1 Application

Application ID	Title
7155	Epidemiology of mental health, cognitive function, pain and cardiometabolic disease.

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