| Title: | A Comparison Between Early Presentation of Dementia with Lewy Bodies, Alzheimer's Disease, and Parkinson's Disease: Evidence from Routine Primary Care and UK Biobank Data |
| Journal: | Annals of Neurology |
| Published: | 11 May 2023 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/37098633/ |
| DOI: | https://doi.org/10.1002/ana.26670 |
| URL: | https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ana.26670 |
Publication 11435
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Abstract
OBJECTIVE: The purpose of this study was to simultaneously contrast prediagnostic clinical characteristics of individuals with a final diagnosis of dementia with Lewy Bodies (DLB), Parkinson's disease (PD), and Alzheimer's disease (AD) compared with controls without neurodegenerative disorders.</p>
METHODS: Using the longitudinal THIN database in the United Kingdom, we tested the association of each neurodegenerative disorder with a selected list of symptoms and broad families of treatments, and compared the associations between disorders to detect disease-specific effects. We replicated the main findings in the UK Biobank.</p>
RESULTS: We used data of 28,222 patients with PD, 20,214 with AD, 4,682 with DLB, and 20,214 healthy controls. All neurodegenerative disorders were significantly associated with the presence of multiple clinical characteristics before their diagnosis, including sleep disorders, falls, psychiatric symptoms, and autonomic dysfunctions. When comparing patients with DLB with patients with PD and patients with AD patients, falls, psychiatric symptoms, and autonomic dysfunction were all more strongly associated with DLB in the 5 years preceding the first neurodegenerative diagnosis. The use of statins was lower in patients who developed PD and higher in patients who developed DLB compared to patients with AD. In patients with PD, the use of statins was associated with the development of dementia in the 5 years following PD diagnosis.</p>
INTERPRETATION: Prediagnostic presentations of falls, psychiatric symptoms, and autonomic dysfunctions were more strongly associated with DLB than PD and AD. This study also suggests that although several associations with medications are similar in neurodegenerative disorders, statin usage is negatively associated with PD but positively with DLB and AD as well as development of dementia in PD. ANN NEUROL 2023;94:259-270.</p>
12 Authors
- Thomas Nedelec
- Baptiste Couvy-Duchesne
- Aube Darves-Bornoz
- Raphaël Couronne
- Fleur Monnet
- Laurène Gantzer
- Béranger Lekens
- Yeda Wu
- Nicolas Villain
- Anette Schrag
- Stanley Durrleman
- Jean-Christophe Corvol
1 Application
| Application ID | Title |
|---|---|
| 53185 | Large-scale decision support systems for the prediction of ageing and ageing-related disorders |
Enabling scientific discoveries that improve human health