| Title: | Overweight, obesity, and risk of hospitalization for COVID-19: A community-based cohort study of adults in the United Kingdom |
| Journal: | Proceedings of the National Academy of Sciences of the United States of America |
| Published: | 11 Aug 2020 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/32788355/ |
| DOI: | https://doi.org/10.1073/pnas.2011086117 |
| Citations: | 184 (36 in last 2 years) as of 8 Aug 2024 |
Publication 12900
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Abstract
The role of obesity and overweight in occurrence of COVID-19 is unknown. We conducted a large-scale general population study using data from a community-dwelling sample in England (n = 334,329; 56.4 ±8.1 y; 54.5% women) with prospective linkage to national registry on hospitalization for COVID-19. Body mass index (BMI, from measured height and weight) was used as an indicator of overall obesity, and waist-hip ratio for central obesity. Main outcome was cases of COVID-19 serious enough to warrant a hospital admission from 16 March 2020 to 26 April 2020. Around 0.2% (n = 640) of the sample were hospitalized for COVID-19. There was an upward linear trend in the likelihood of COVID-19 hospitalization with increasing BMI, that was evident in the overweight (odds ratio, 1.39; 95% CI 1.13 to 1.71; crude incidence 19.1 per 10,000) and obese stage I (1.70;1.34 to 2.16; 23.3 per 10,000) and stage II (3.38; 2.60 to 4.40; 42.7 per 10,000) compared to normal weight (12.5 per 10,000). This gradient was little affected after adjustment for a wide range of covariates; however, controlling for biomarkers, particularly high-density lipoprotein cholesterol and glycated hemoglobin, led to a greater degree of attenuation. A similar pattern of association emerged for waist-hip ratio. In summary, overall and central obesity are risk factors for COVID-19 hospital admission. Elevated risk was apparent even at modest weight gain. The mechanisms may involve impaired glucose and lipid metabolism.</p>
20 Keywords
- Adult
- Aged
- Betacoronavirus
- Body Mass Index
- COVID-19
- Cohort Studies
- Coronavirus Infections
- Female
- Hospitalization
- Humans
- Male
- Middle Aged
- Obesity
- Overweight
- Pandemics
- Pneumonia, Viral
- Risk Factors
- SARS-CoV-2
- United Kingdom
- White People
4 Authors
- Mark Hamer
- Catharine R. Gale
- Mika Kivimäki
- G. David Batty
1 Application
| Application ID | Title |
|---|---|
| 10279 | The relationship of cognitive function and negative emotions with morbidity and mortality: an aetiological investigation |
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