| Title: | Unique genetic and risk-factor profiles in clusters of major depressive disorder-related multimorbidity trajectories |
| Journal: | Nature Communications |
| Published: | 21 Aug 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/39168988/ |
| DOI: | https://doi.org/10.1038/s41467-024-51467-7 |
| URL: | https://www.nature.com/articles/s41467-024-51467-7.pdf |
Publication 13105
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Abstract
The heterogeneity and complexity of symptom presentation, comorbidities and genetic factors pose challenges to the identification of biological mechanisms underlying complex diseases. Current approaches used to identify biological subtypes of major depressive disorder (MDD) mainly focus on clinical characteristics that cannot be linked to specific biological models. Here, we examined multimorbidities to identify MDD subtypes with distinct genetic and non-genetic factors. We leveraged dynamic Bayesian network approaches to determine a minimal set of multimorbidities relevant to MDD and identified seven clusters of disease-burden trajectories throughout the lifespan among 1.2 million participants from cohorts in the UK, Finland, and Spain. The clusters had clear protective- and risk-factor profiles as well as age-specific clinical courses mainly driven by inflammatory processes, and a comprehensive map of heritability and genetic correlations among these clusters was revealed. Our results can guide the development of personalized treatments for MDD based on the unique genetic, clinical and non-genetic risk-factor profiles of patients.</p>
15 Keywords
- Adult
- Aged
- Bayes Theorem
- Depressive Disorder, Major
- Female
- Finland
- Genetic Predisposition to Disease
- Humans
- Male
- Middle Aged
- Multimorbidity
- Risk Factors
- Spain
- United Kingdom
- Young Adult
21 Authors
- Andras Gezsi
- Sandra Van der Auwera
- Hannu Mäkinen
- Nora Eszlari
- Gabor Hullam
- Tamas Nagy
- Sarah Bonk
- Rubèn González-Colom
- Xenia Gonda
- Linda Garvert
- Teemu Paajanen
- Zsofia Gal
- Kevin Kirchner
- Andras Millinghoffer
- Carsten O. Schmidt
- Bence Bolgar
- Josep Roca
- Isaac Cano
- Mikko Kuokkanen
- Peter Antal
- Gabriella Juhasz
1 Application
| Application ID | Title |
|---|---|
| 1602 | Association between diet and depression |
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