| Title: | Kidney Injury Evoked by Fine Particulate Matter: Risk Factor, Causation, Mechanism and Intervention Study |
| Journal: | Advanced Science |
| Published: | 24 Sep 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/39316383/ |
| DOI: | https://doi.org/10.1002/advs.202403222 |
Publication 13446
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Abstract
Fine particulate matter (PM2.5) is suggested to pose a severe risk to the kidneys by inducing functional degradation and chronic kidney diseases (CKD). This study aims to explore the nephrotoxicity of PM2.5 exposure and the underlying mechanism. Herein, based on the UK Biobank, it is found that per interquartile range (IQR) increase in PM2.5 is associated with a 6% (95% CI: 1%-11%), 7% (95% CI: 3%-11%), 9% (95% CI: 4%-13%), 11% (95% CI: 9%-13%), and 10% (95% CI: 8%-12%) increase in the risk of nephritis, hydronephrosis, kidney stone, acute renal failure, and CKD, respectively. In experimental study, noticeable kidney injury, which is the initiation of kidney diseases, is observed with PM2.5 exposure in C57BL/6N mice (n = 8), accompanied with oxidative stress, autophagy and pyroptosis. In vitro, HK-2 cells with PM2.5-stimulation exhibit tubulopathy, increased reactive oxygen species (ROS) generation and activated pyroptosis and autophagy. All changes are abolished by ROS scavenger of N-acetyl-L-cysteine (NAC) both in vivo and in vitro. In conclusion, the study provides evidence showing that PM2.5 exposure is associated with 5 kinds of kidney diseases by directly inducing nephrotoxicity, in which ROS may be the potential target by triggering autophagy and pyroptosis.</p>
17 Authors
- Tong Hou
- Yuqing Jiang
- Jiyang Zhang
- Renjie Hu
- Sanduo Li
- Wenjun Fan
- Rucheng Chen
- Lu Zhang
- Ran Li
- Li Qin
- Weijia Gu
- Yue Wu
- Lina Zhang
- Xiang Zeng
- Qinghua Sun
- Yingying Mao
- Cuiqing Liu
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