| Title: | Dietary vitamin B3 supplementation induces the antitumor immunity against liver cancer via biased GPR109A signaling in myeloid cell |
| Journal: | Cell Reports Medicine |
| Published: | 17 Sep 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/39293389/ |
| DOI: | https://doi.org/10.1016/j.xcrm.2024.101718 |
Publication 13652
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Abstract
The impact of dietary nutrients on tumor immunity remains an area of ongoing investigation, particularly regarding the specific role of vitamins and their mechanism. Here, we demonstrate that vitamin B3 (VB3) induces antitumor immunity against liver cancer through biased GPR109A axis in myeloid cell. Nutritional epidemiology studies suggest that higher VB3 intake reduces liver cancer risk. VB3 supplementation demonstrates antitumor efficacy in multiple mouse models through alleviating the immunosuppressive tumor microenvironment (TME) mediated by tumor-infiltrating myeloid cell, thereby augmenting effectiveness of immunotherapy or targeted therapy in a CD8+ T cell-dependent manner. Mechanically, the TME induces aberrant GPR109A/nuclear factor κB (NF-κB) activation in myeloid cell to shape the immunosuppressive TME. In contrast, VB3 activates β-Arrestin-mediated GPR109A degradation and NF-κB inhibition to suppress the immunosuppressive polarization of myeloid cell, thereby activating the cytotoxic function of CD8+ T cell. Overall, these results expand the understanding of how vitamins regulate the TME, suggesting that dietary VB3 supplementation is an adjunctive treatment for liver cancer.</p>
15 Keywords
- Animals
- CD8-Positive T-Lymphocytes
- Cell Line, Tumor
- Dietary Supplements
- Humans
- Liver Neoplasms
- Male
- Mice
- Mice, Inbred C57BL
- Myeloid Cells
- NF-kappa B
- Receptors, G-Protein-Coupled
- Receptors, Nicotinic
- Signal Transduction
- Tumor Microenvironment
13 Authors
- Yang Yang
- Tianduo Pei
- Xiaolin Hu
- Yu Lu
- Yanqiu Huang
- Tingya Wan
- Chaobao Liu
- Fengqian Chen
- Bao Guo
- Yuemei Hong
- Qian Ba
- Xiaoguang Li
- Hui Wang
1 Application
| Application ID | Title |
|---|---|
| 194423 | Interplay among dietary pattern, lifestyles, mental well-being, and genetic predispositions in non-communicable diseases |
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