| Title: | Sleep characteristics and HbA1c in patients with type 2 diabetes on glucose-lowering medication |
| Journal: | BMJ Open Diabetes Research & Care |
| Published: | 31 Aug 2020 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/32868313/ |
| DOI: | https://doi.org/10.1136/bmjdrc-2020-001702 |
| URL: | https://drc.bmj.com/content/bmjdrc/8/1/e001702.full.pdf |
Publication 13693
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Abstract
INTRODUCTION: To examine the association of sleep duration, insomnia, and obstructive sleep apnea (OSA) with hemoglobin A1c (HbA1c) in a cohort of patients with type 2 diabetes (T2D) on glucose-lowering medications.</p>
RESEARCH DESIGN AND METHODS: 13 346 patients with T2D were included in the present analysis (mean age: 60.2 years; 56.6% were on antidiabetic drug monotherapy; 43.4% received at least two glucose-lowering medications). Sleep duration (short: ≤6 hours/day; normal: 7-8 hours/day; long: ≥9 hours/day) and frequency of insomnia symptoms were self-reported. The risk of OSA was considered high if at least two of the following conditions were fulfilled: regular snoring, frequent daytime sleepiness, and either obesity (≥30 kg/m2) or hypertension (systolic blood pressure ≥140 mm Hg or diastolic blood pressure ≥90 mm Hg). Associations between sleep variables and HbA1c were investigated by analysis of covariance or linear regression (adjusted for, eg, participants' age, sex, ethnic background, and systolic blood pressure).</p>
RESULTS: Long sleep duration and a high risk for OSA were independently associated with higher HbA1c values (long vs normal sleep duration: +0.10% (95% CI 0.03 to 0.18); high vs low risk for OSA: +0.07% (95% CI 0.02 to 0.11), both p=0.004). No robust association was found of short sleep duration and frequent insomnia symptoms with HbA1c. Finally, a positive dose-response association between the number of sleep problems per subject (range: 0-3) and HbA1c was observed (β=0.04% (0.02 to 0.06), p=0.002). However, all significant associations were small.</p>
CONCLUSION: Screening for and treatment of sleep problems may help lower HbA1c levels in patients with T2D on glucose-lowering medications.</p>
7 Keywords
- Blood Glucose
- Diabetes Mellitus, Type 2
- Glucose
- Glycated Hemoglobin
- Humans
- Middle Aged
- Sleep
2 Authors
- Xiao Tan
- Christian Benedict
1 Application
| Application ID | Title |
|---|---|
| 55177 | Role of sleep and circadian rhythm in treatment efficacy of antidiabetics |
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