| Title: | Longitudinal changes in serum testosterone and sex hormone-binding globulin in men aged 40-69 years from the UK Biobank |
| Journal: | Clinical Endocrinology |
| Published: | 6 Dec 2021 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/34873743/ |
| DOI: | https://doi.org/10.1111/cen.14648 |
Publication 13825
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Abstract
OBJECTIVE: Testosterone and sex hormone-binding globulin (SHBG) concentrations are reported to decline during male ageing, but whether these changes reflect physiological ageing or age-related comorbidities remains uncertain. We examined longitudinal changes in serum testosterone and SHBG concentrations in middle-aged to older men, concordance between baseline and follow-up values and relationships with concomitant changes in lifestyle and medical factors.</p>
DESIGN: Population-based longitudinal cohort study.</p>
PARTICIPANTS: Community-dwelling men aged 40-69 years.</p>
MEASUREMENTS: Immunoassay serum total testosterone (n = 7812) and SHBG (n = 6491) at baseline (2006-2010) and follow-up (2012-2013). Free testosterone (cFT) was calculated. Bland-Altman analyses and concordance correlation of repeated measurements were conducted. Associations of changes in hormone concentrations with lifestyle and medical factors were explored using Spearman's rank correlation.</p>
RESULTS: Over 4.3 years follow-up, there was a negligible mean change (±SE) in serum total testosterone concentration (+0.06 ± 0.03 nmol/L), whereas mean SHBG concentration increased (+3.69 ± 0.12 nmol/L) and cFT decreased (-10.7 ± 0.7 pmol/L). Concordance estimates were 0.67 (95% confidence interval [CI]: 0.66-0.69) for total testosterone, 0.83 (CI = 0.82-0.84) for SHBG and 0.56 (CI = 0.54-0.58) for cFT. Changes in serum total testosterone correlated with changes in SHBG (Spearman's rank ρ = 0.33, CI = 0.30-0.35), and inversely with changes in body mass index (BMI) (ρ = -0.18, CI = -0.20 to -0.16) and waist circumference (ρ = -0.13, CI = -0.15 to -0.11) and in SHBG with changes in BMI (ρ = -0.34, CI = -0.36 to -0.32) and waist circumference (ρ = -0.21, CI = -0.24 to -0.19).</p>
CONCLUSION: In relatively healthy middle-aged to older men, mean serum total testosterone concentration is stable with ageing, while mean SHBG concentration increases. Both total testosterone and SHBG concentrations were highly concordant over time.</p>
9 Keywords
- Aged
- Biological Specimen Banks
- Humans
- Longitudinal Studies
- Male
- Middle Aged
- Sex Hormone-Binding Globulin
- Testosterone
- United Kingdom
7 Authors
- Ross J. Marriott
- Kevin Murray
- Graeme J. Hankey
- Laurens Manning
- Girish Dwivedi
- Frederick C. W. Wu
- Bu B. Yeap
1 Application
| Application ID | Title |
|---|---|
| 54680 | Sex hormones as predictors of key health outcomes in men from the UK Biobank |
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