| Title: | Evaluating causal associations of chronotype with pregnancy and perinatal outcomes and its interactions with insomnia and sleep duration: a mendelian randomization study |
| Journal: | BMC Pregnancy and Childbirth |
| Published: | 18 Dec 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/39696061/ |
| DOI: | https://doi.org/10.1186/s12884-024-07023-8 |
Publication 13970
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Abstract
BackgroundObservational studies suggested chronotype was associated with pregnancy and perinatal outcomes. Whether these associations are causal is unclear. Our aims are to use Mendelian randomization (MR) to explore (1) associations of evening preference with stillbirth, miscarriage, gestational diabetes, hypertensive disorders of pregnancy, perinatal depression, preterm birth and offspring birthweight; and (2) differences in associations of insomnia and sleep duration with those outcomes between chronotype preferences.MethodsWe conducted two-sample MR using 105 genetic variants reported in a genome-wide association study (N = 248,100) to instrument for lifelong predisposition to evening- versus morning-preference. We generated variant-outcome associations in European ancestry women from UK Biobank (UKB, N = 176,897), Avon Longitudinal Study of Parents and Children (ALSPAC, N = 6826), Born in Bradford (BiB, N = 2940) and the Norwegian Mother, Father and Child Cohort Study (MoBa, N = 57,430), and extracted equivalent associations from FinnGen (N = 190,879). We used inverse variance weighted (IVW) as main analysis, with weighted median and MR-Egger as sensitivity analyses. Relying on the individual participant data from UKB, ALSPAC, BiB and MoBa, we also conducted IVW analyses of insomnia and sleep duration on the pregnancy and perinatal outcomes, stratified by genetically predicted chronotypes.ResultsIn IVW and sensitivity analyses, we did not find robust evidence of associations of chronotype with the outcomes. Insomnia was associated with a higher risk of preterm birth among evening preference women (odds ratio 1.61, 95% confidence interval: 1.17, 2.21), but not among morning preference women (odds ratio 0.87, 95% confidence interval: 0.64, 1.18), with an interaction P-value = 0.01. There was no evidence of interactions between insomnia and chronotype on other outcomes, or between sleep duration and chronotype on any outcomes.ConclusionsThis study raises the possibility of a higher risk of preterm birth among women with insomnia who also have an evening preference. Our findings warrant replications due to imprecise estimates.</p>
16 Keywords
- Adult
- Chronotype
- Circadian Rhythm
- Female
- Genome-Wide Association Study
- Humans
- Longitudinal Studies
- Mendelian Randomization Analysis
- Pregnancy
- Pregnancy Complications
- Pregnancy Outcome
- Premature Birth
- Sleep
- Sleep Duration
- Sleep Initiation and Maintenance Disorders
- United Kingdom
12 Authors
- Qian Yang
- Maria C. Magnus
- Fanny Kilpi
- Gillian Santorelli
- Ana Goncalves Soares
- Jane West
- Per Magnus
- Siri E. Håberg
- Kate Tilling
- Deborah A Lawlor
- M Carolina Borges
- Eleanor Sanderson
1 Application
| Application ID | Title |
|---|---|
| 23938 | Causal effect of maternal vitamin D levels and body mass index on pregnancy-related outcomes |
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