| Title: | Brain-specific genes contribute to chronic but not to acute back pain |
| Journal: | PAIN Reports |
| Published: | 9 Aug 2022 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/35975136/ |
| DOI: | https://doi.org/10.1097/pr9.0000000000001018 |
Publication 14125
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Abstract
Introduction: Back pain is the leading cause of disability worldwide. Although most back pain cases are acute, 20% of acute pain patients experience chronic back pain symptoms. It is unclear whether acute pain and chronic pain have similar or distinct underlying genetic mechanisms.</p>
Objectives: To characterize the molecular and cellular pathways contributing to acute and chronic pain states.</p>
Methods: Cross-sectional observational genome-wide association study.</p>
Results: A total of 375,158 individuals from the UK Biobank cohort were included in the discovery of genome-wide association study. Of those, 70,633 (19%) and 32,209 (9%) individuals met the definition of chronic and acute back pain, respectively. A total of 355 single nucleotide polymorphism grouped into 13 loci reached the genome-wide significance threshold (5x10-8) for chronic back pain, but none for acute. Of these, 7 loci were replicated in the Nord-Trøndelag Health Study (HUNT) cohort (19,760 chronic low back pain cases and 28,674 pain-free controls). Single nucleotide polymorphism heritability was 4.6% (P=1.4x10-78) for chronic back pain and 0.81% (P=1.4x10-8) for acute back pain. Similar differences in heritability estimates between acute and chronic back pain were found in the HUNT cohort: 3.4% (P=0.0011) and 0.6% (P=0.851), respectively. Pathway analyses, tissue-specific heritability enrichment analyses, and epigenetic characterization suggest a substantial genetic contribution to chronic but not acute back pain from the loci predominantly expressed in the central nervous system.</p>
Conclusion: Chronic back pain is substantially more heritable than acute back pain. This heritability is mostly attributed to genes expressed in the brain.</p>
10 Authors
- Andrey V. Bortsov
- Marc Parisien
- Samar Khoury
- Amy E. Martinsen
- Marie Udnesseter Lie
- Ingrid Heuch
- Kristian Hveem
- John-Anker Zwart
- Bendik S. Winsvold
- Luda Diatchenko
1 Application
| Application ID | Title |
|---|---|
| 20802 | A replication study of pain interactions with comorbidities |
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