| Title: | Allometric fat mass index and alanine aminotransferase attenuate the associations of platelet parameters with lung cancer risk |
| Journal: | Scientific Reports |
| Published: | 1 Nov 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/39487349/ |
| DOI: | https://doi.org/10.1038/s41598-024-78281-x |
Publication 14148
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Abstract
We have previously shown that body mass index attenuates a positive association of platelet count (PLT) and inverse of mean platelet volume (MPV) with lung cancer risk in men. It is unclear whether fat mass, lean mass, or liver function tests (LFTs) show similar attenuations. Using bioelectrical impedance measurements (UK Biobank cohort) and multivariable Cox proportional hazards models, we examined the associations of allometric fat-mass index (AFI, fat mass adjusted for height), allometric lean-mass index (ALI, fat-free mass adjusted for height and fat mass), and LFTs with lung cancer risk and their multiplicative and additive interactions with platelet parameters. Based on 1573 lung cancer cases in men and 1473 in women with body composition measurements (1541 in men; 1428 in women with biomarker measurements), AFI in women, ALI in both sexes, alanine aminotransferase (ALT) and total bilirubin in men were inversely associated, while gamma-glutamyl transferase in men and alkaline phosphatase in both sexes were positively associated with lung cancer risk. Only AFI and ALT interacted inversely with PLT and positively with MPV in men. The attenuation of the associations of platelet parameters with lung cancer risk by high-AFI and high-ALT in men suggests that adiposity-related factors hinder lung-cancer-related platelet associations.</p>
15 Keywords
- Adult
- Aged
- Alanine Transaminase
- Blood Platelets
- Body Composition
- Body Mass Index
- Female
- Humans
- Lung Neoplasms
- Male
- Mean Platelet Volume
- Middle Aged
- Platelet Count
- Proportional Hazards Models
- Risk Factors
4 Authors
- Sofia Christakoudi
- Konstantinos K. Tsilidis
- Marc J. Gunter
- Elio Riboli
1 Application
| Application ID | Title |
|---|---|
| 41952 | Obesity, body shape, nutrition, hypertension, steroid hormones and vitamin D: associations, interactions and contribution to metabolic health and the risk of cancer development and survival |
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