| Title: | Genetic legacy of ancient hunter-gatherer Jomon in Japanese populations |
| Journal: | Nature Communications |
| Published: | 12 Nov 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/39532881/ |
| DOI: | https://doi.org/10.1038/s41467-024-54052-0 |
Publication 14191
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Abstract
The tripartite ancestral structure is a recently proposed model for the genetic origin of modern Japanese, comprising indigenous Jomon hunter-gatherers and two additional continental ancestors from Northeast Asia and East Asia. To investigate the impact of the tripartite structure on genetic and phenotypic variation today, we conducted biobank-scale analyses by merging Biobank Japan (BBJ; n = 171,287) with ancient Japanese and Eurasian genomes (n = 22). We demonstrate the applicability of the tripartite model to Japanese populations throughout the archipelago, with an extremely strong correlation between Jomon ancestry and genomic variation among individuals. We also find that the genetic legacy of Jomon ancestry underlies an elevated body mass index (BMI). Genome-wide association analysis with rigorous adjustments for geographical and ancestral substructures identifies 132 variants that are informative for predicting individual Jomon ancestry. This prediction model is validated using independent Japanese cohorts (Nagahama cohort, n = 2993; the second cohort of BBJ, n = 72,695). We further confirm the phenotypic association between Jomon ancestry and BMI using East Asian individuals from UK Biobank (n = 2286). Our extensive analysis of ancient and modern genomes, involving over 250,000 participants, provides valuable insights into the genetic legacy of ancient hunter-gatherers in contemporary populations.</p>
14 Keywords
- Biological Specimen Banks
- Body Mass Index
- East Asian People
- Female
- Genetic Variation
- Genetics, Population
- Genome, Human
- Genome-Wide Association Study
- Humans
- Japan
- Male
- Middle Aged
- Phenotype
- Polymorphism, Single Nucleotide
19 Authors
- Kenichi Yamamoto
- Shinichi Namba
- Kyuto Sonehara
- Ken Suzuki
- Saori Sakaue
- Niall P. Cooke
- Shinichi Higashiue
- Shuzo Kobayashi
- Hisaaki Afuso
- Kosho Matsuura
- Yojiro Mitsumoto
- Yasuhiko Fujita
- Torao Tokuda
- Koichi Matsuda
- Takashi Gakuhari
- Toshimasa Yamauchi
- Takashi Kadowaki
- Shigeki Nakagome
- Yukinori Okada
1 Application
| Application ID | Title |
|---|---|
| 47821 | Trans-ethnic GWAS meta-analysis and exploration of trait-relevant genetic architecture. |
Enabling scientific discoveries that improve human health