| Title: | Association of coffee consumption and caffeine metabolism with arrhythmias and cardiac morphology: an observational, genetic and Mendelian Randomization study |
| Journal: | Heart Rhythm |
| Published: | 27 Nov 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/39613205/ |
| DOI: | https://doi.org/10.1016/j.hrthm.2024.11.047 |
Publication 14250
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Abstract
BACKGROUND: The association of coffee intake and caffeine metabolism with arrhythmias and cardiac structure is not fully understood.</p>
OBJECTIVE: We aim to explore the associations of coffee intake and caffeine metabolism with the risk of certain types of arrhythmias, a broad range of cardiovascular imaging phenotypes, and a potential gene-coffee interaction.</p>
METHODS: On the basis of the UK Biobank imaging study, heart metrics were extracted via cardiovascular magnetic resonance using machine learning. Caffeine metabolism was determined by cytochrome P4501A2 gene (CYP1A2) or a polygenetic score of different genetic variants influencing caffeine metabolism. Genome-wide association data for 2-sample Mendelian randomization originated predominantly from individuals of European descent.</p>
RESULTS: A total of 34,992 individuals (mean age 63.5 ± 7.5 years; 18,506 [52.9%] female) were assessed in the principal imaging analysis. Higher daily consumption of coffee was independently associated with higher left ventricular mass, larger global ventricular volume, higher ventricular stroke volume, and larger atrial volume. The results were further supported by Mendelian randomization analysis. CYP1A2 and genetic score for caffeine metabolism were not associated with cardiovascular measurements (P>.053 for all tests). Coffee consumption was associated with a lower risk of sinus rhythm with a short PR interval (per cup increase: odds ratio 0.90; 95% confidence interval 0.82-0.99) and atrial fibrillation (odds ratio 0.89; 95% confidence interval 0.84-0.93).</p>
CONCLUSION: Coffee consumption was associated with a lower risk of atrial fibrillation, increased left ventricular mass, elevated ventricular volume, and larger atrial volume. Caffeine metabolism did not significantly alter the association. Our results suggest that customary caffeine consumption limitations aimed at arrhythmia risk reduction might be unnecessary.</p>
15 Authors
- Jiazhen Zheng
- Haowen Chen
- Quan Yang
- Zhen Zhou
- Chuang Yang
- Jinghan Huang
- Qiang Tu
- Haisheng Wu
- Peng Qiu
- Wenbo Huang
- Wenming Shi
- Mifen Chen
- Huamin Liu
- Junchun Shen
- Shaojun Tang
1 Application
| Application ID | Title |
|---|---|
| 97089 | Associations of physical multimorbidity patterns and heart structure with cognition and neuroimaging outcomes |
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