| Title: | Plasma proteomic biomarkers as mediators or moderators for the association between poor cardiovascular health and white matter microstructural integrity: The UK Biobank study |
| Journal: | Alzheimer's & Dementia |
| Published: | 17 Jan 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/39822062/ |
| DOI: | https://doi.org/10.1002/alz.14507 |
Publication 14496
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Abstract
INTRODUCTION: The plasma proteome's mediating or moderating roles in the association between poor cardiovascular health (CVH) and brain white matter (WM) microstructural integrity are largely unknown.</p>
METHODS: Data from 3953 UK Biobank participants were used (40-70 years, 2006-2010), with a neuroimaging visit between 2014 and 2021. Poor CVH was determined using Life's Essential 8 (LE8) and reversing standardized z-scores (LE8z _rev). The plasma proteome was examined as a potential mediator or moderator of LE8z _rev's effects on quantitative diffusion-weighted magnetic resonance imaging (dMRI) metrics.</p>
RESULTS: LE8z_rev was significantly associated with deteriorated WM microstructural integrity, as reflected by lower tract-averaged fractional anisotropy (dMRI-FAmean), (β ± standared error (SE): -0.00152 ± 0.0003, p < 0.001) and higher tract-averaged orientation dispersion (dMRI-ODmean), (β ± SE:+0.00081 ± 0.00017, p < 0.001). Ten strongly mediating plasma proteins of 1463 were identified, with leptin as the principal driver.</p>
DISCUSSION: Poor CVH is linked to poor WM microstructural integrity measures (lower FAmean and higher ODmean), mostly mediated through leptin.</p>
HIGHLIGHTS: Up to 3953 UK Biobank participants were selected for this study. Poor cardiovascular health (CVH) was determined using Life's Essential 8. The plasma proteome was examined as a potential mediator or moderator of poor CVH's effect on dMRI metrics. Ten plasma proteins were identified with strong mediating effects, with leptin being the principal driver.</p>
16 Keywords
- Adult
- Aged
- Biological Specimen Banks
- Biomarkers
- Blood Proteins
- Cardiovascular Diseases
- Diffusion Magnetic Resonance Imaging
- Female
- Humans
- Male
- Middle Aged
- Proteome
- Proteomics
- UK Biobank
- United Kingdom
- White Matter
14 Authors
- May A. Beydoun
- Hind A. Beydoun
- Nicole Noren Hooten
- Zhiguang Li
- Yi-Han Hu
- Michael F. Georgescu
- Sharmin Hossain
- Toshiko Tanaka
- Mustapha Bouhrara
- Christian A. Maino Vieytes
- Marie T. Fanelli-Kuczmarski
- Lenore J. Launer
- Michele K. Evans
- Alan B. Zonderman
1 Application
| Application ID | Title |
|---|---|
| 77963 | Dissecting racial/ethnic disparities in dementia traits through socio-economic, lifestyle, cardio-metabolic risk and infectious agents, with focus on Helicobacter pylori sero-positivity |
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