| Title: | Inflammatory markers link triglyceride-glucose index and obesity indicators with adverse cardiovascular events in patients with hypertension: insights from three cohorts |
| Journal: | Cardiovascular Diabetology |
| Published: | 8 Jan 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/39780176/ |
| DOI: | https://doi.org/10.1186/s12933-024-02571-x |
| URL: | https://cardiab.biomedcentral.com/counter/pdf/10.1186/s12933-024-02571-x |
Publication 14548
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Abstract
BackgroundAmong hypertensive cohorts across different nations, the relationship between the triglyceride-glucose index (TyG) and its conjunction with obesity metrics in relation to cardiovascular disease (CVD) incidence and mortality remains to be elucidated.MethodsThis study enrolled 9,283, 164,357, and 5,334 hypertensives from the National Health and Nutrition Examination Survey (NHANES), UK Biobank (UKBB), and Shanghai Pudong cohort. The related outcomes for CVD were defined by multivariate Cox proportional hazards models, Generalized Additive Models and Mendelian randomization analysis. Mediation analysis explored the mediating role of inflammatory markers in the above relationships.ResultsFive measures of insulin resistance were linked to CVD and related death in a U-shaped pattern, with the highest group having different risk increases. Higher glucose triglyceride-waist height ratio (TyG-WHTR) was linked to higher all-cause mortality (UKBB: HR 1.21, 95%CI 1.16-1.26, NHANES: HR 1.17, 95%CI 1.00-1.36), CVD mortality (UKBB: HR 1.36, 95%CI 1.23-1.49, NHANES: HR 1.32, 95%CI 1.00-1.72) risks. In the China Pudong cohort, higher triglyceride/high-density lipoprotein-cholesterol (TG/HDL_C) ratio was associated with higher risks of CVD and stroke (HR 1.31, 95%CI 1.00-1.73 and 1.67, 1.06-2.63). Inflammation markers like systemic inflammatory response index (SIRI) and C-reactive protein (CRP) partially explained these links, with CRP having a stronger effect. Genetically predicted TyG was also linked to stroke (OR 1.26, 95%CI 1.10-1.45) risk.ConclusionsAn elevated TyG index and its related indices are significantly correlated with an increased risk of CVD and related mortality across three national cohorts. These indices are anticipated to serve as valid predictors of incident CVD and mortality in individuals with hypertension.Graphical abstract</p>
25 Keywords
- Adult
- Aged
- Biomarkers
- Blood Glucose
- Blood Pressure
- Cardiovascular Diseases
- China
- Female
- Humans
- Hypertension
- Incidence
- Inflammation
- Inflammation Mediators
- Insulin Resistance
- Male
- Mendelian Randomization Analysis
- Middle Aged
- Nutrition Surveys
- Obesity
- Prognosis
- Risk Assessment
- Risk Factors
- Time Factors
- Triglycerides
- United States
15 Authors
- Yanqiu Huang
- Yi Zhou
- Yadan Xu
- Xiaoyu Wang
- Ziyi Zhou
- Kang Wu
- Qiqi Meng
- Liao Wang
- Yang Yang
- Hong Gao
- Juan Ji
- Xu Jiang
- Yang Yang
- Lipeng Hao
- Hui Wang
1 Application
| Application ID | Title |
|---|---|
| 89871 | Identifying risk factors for osteoarthritis and osteoporosis in UK Biobank: a longitudinal cohort study |
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