| Title: | Genetic and Environmental Risk for Chronic Pain and the Contribution of Risk Variants for Major Depressive Disorder: A Family-Based Mixed-Model Analysis |
| Journal: | PLoS Med |
| Published: | 1 Aug 2016 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/27529168/ |
| DOI: | https://doi.org/10.1371/journal.pmed.1002090 |
Publication 1665
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Abstract
Depression and chronic pain are known to be associated with each other. In this study, published in PLoS Medicine, we sought to examine whether risk of chronic pain was, like depression, conferred by the action of many genetic changes, each of small effect. Secondly, we then sought to test whether there were shared environmental contributions to chronic pain that might also explain similarities between affected family members. Thirdly, we tested whether chronic pain and depression shared overlapping genetic risk factors. Our results found that chronic pain risk was due to the action of many genetic risk factors, but that the environments shared by people in partner/spouse relationships was also important. We also found that these genetic risk factors and shared environments were common to both chromic pain and depression, and could partly explain their correlation.1 Author
- McIntosh AM et al.
1 Application
| Application ID | |
|---|---|
| 4844 | STratifying Resilience and Depression Longitudinally (STRADL) |
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