| Title: | Genome-wide association study of depression phenotypes in UK Biobank identifies variants in excitatory synaptic pathways |
| Journal: | Nat Commun |
| Published: | 16 Apr 2018 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/29662059/ |
| DOI: | https://doi.org/10.1038/s41467-018-03819-3 |
Publication 1879
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Abstract
Depression is a polygenic trait that causes extensive periods of disability. Previous genetic studies have identified common risk variants which have progressively increased in number with increasing sample sizes of the respective studies. Here, we conduct a genome-wide association study in 322,580 UK Biobank participants for three depression-related phenotypes: broad depression, probable major depressive disorder (MDD), and International Classification of Diseases (ICD, version 9 or 10)-coded MDD. We identify 17 independent loci that are significantly associated (P < 5 x 10^-8) across the three phenotypes. The direction of effect of these loci is consistently replicated in an independent sample, with 14 loci likely representing novel findings. Gene sets are enriched in excitatory neurotransmission, mechanosensory behaviour, post synapse, neuron spine and dendrite functions. Our findings suggest that broad depression is the most tractable UK Biobank phenotype for discovering genes and gene sets that further our understanding of the biological pathways underlying depression.1 Author
- Howard DM et al.
1 Application
| Application ID | Title |
|---|---|
| 4844 | STratifying Resilience and Depression Longitudinally (STRADL) |
Enabling scientific discoveries that improve human health