| Title: | Insight Into the Biological Link Between Novel Adiposity Indices and Incident Heart Failure |
| Journal: | Comprehensive Physiology |
| Published: | 30 Jun 2026 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/42381241/ |
| DOI: | https://doi.org/10.1002/cph4.70206 |
Publication 20814
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Abstract
OBJECTIVE: Obesity is a well-known heart failure (HF) risk factor, yet the biological pathways linking adiposity indices to HF remain unclear. This study aimed to identify proteomic mediators for five novel indices-waist circumference (WC), waist-to-hip ratio (WHR), waist-to-height ratio (WHTR), body roundness index (BRI), weight-adjusted waist index (WWI), and translate mechanistic differences into clinical practice.</p>
METHODS: Using UK Biobank data, we applied Cox regression and linear regression to identify proteins associated with both HF and each index, followed by mediation and GO enrichment analyses.</p>
RESULTS: All five indices were associated with HF, with WHR and WHTR showing the strongest links. Shared pathways included angiogenesis and cardiac development. Each index occupied a distinct position along a pathological continuum: BRI (cell surface-related) as the upstream driver of early adipose dysfunction; WHR (inflammatory-fibrotic cascade) and WHTR (developmental-metabolic-inflammatory-hormonal) as intermediate downstream markers; WWI (vascular development) and WC (extracellular matrix remodeling) as terminal downstream markers of established organ damage.</p>
CONCLUSIONS: Each indicator occupies a distinct position in HF progression, offering unique mechanistic insights into its onset, and thus enabling individualized risk assessment and mechanism-based interventions for obese patients.</p>
10 Keywords
- Adiposity
- Female
- Heart Failure
- Humans
- Male
- Obesity
- Proteomics
- Waist Circumference
- Waist-Height Ratio
- Waist-Hip Ratio
10 Authors
- Yunyao Yang
- Jiayong Li
- Xixi Xiao
- Yu Ning
- Zhen Ou
- Siyu Guo
- Xin He
- Chen Liu
- Bin Dong
- Ruicong Xue
1 Application
| Application ID | Title |
|---|---|
| 99231 | The association between cardiac dysfunction and novel risk factors in chronic kidney disease |
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