| Title: | Genome-Wide Association Study Identifies Human Genetic Variants Associated with Systemic Chronic Inflammation |
| Journal: | OMICS A Journal of Integrative Biology |
| Published: | 11 Jun 2026 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/42275006/ |
| DOI: | https://doi.org/10.1177/15578100261458847 |
Publication 20833
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Abstract
Chronic low-grade inflammation has been identified as the etiology of disease across the life span; however, the underlying genetic mechanism are poorly understood, and no genetic association study is performed. Here, we quantified chronic low-grade inflammation using the low-grade inflammation score (INFLA-score) and performed a genome-wide association study in a large European cohort of 217,984 individuals, involving 6,134,151 single nucleotide polymorphisms (SNPs). We identified 20,182 SNPs at 194 loci reaching genome-wide significance (p < 5 × 10-8), with the lead SNP rs429358 in apolipoprotein E (APOE) showing an extremely low p-value of 8.69 × 10-166. Gene analysis found 470 genes with p < 2.70 × 10-6 (0.05/18,519), among which phosphodiesterase 4B was most significant (p = 1.67 × 10-22). Among those, 15 SNPs were first reported, including GS1-259H13.10, AC068533.7, AL355490.1, and so on. Tissue expression analysis revealed significant links between genetic variants and chronic low-grade inflammation in spleen and whole blood. Our findings identify variants linked to chronic low-grade inflammation and related inflammatory and cellular regulation traits, and suggest a close association between chronic low-grade inflammation and the spleen.</p>
9 Keywords
- Apolipoproteins E
- Chronic Disease
- Female
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Humans
- Inflammation
- Male
- Polymorphism, Single Nucleotide
5 Authors
- Jiayi Xue
- Wenxin Sun
- Peipei Liu
- Jingyu Wang
- Youxin Wang
1 Application
| Application ID | Title |
|---|---|
| 65711 | The association of metabolic trajectory with cardiovascular events, cancers events and all-cause death based on cohort study and Mendelian randomization study |
Enabling scientific discoveries that improve human health