| Title: | Intrinsic Capacity, Genetic Susceptibility and Incident Cardiovascular Disease Among Individuals With Diabetes: A Prospective Cohort Study |
| Journal: | Diabetes Obesity and Metabolism |
| Published: | 10 Jun 2026 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/42271486/ |
| DOI: | https://doi.org/10.1111/dom.70990 |
Publication 20836
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Abstract
BACKGROUND: The relationship between intrinsic capacity (IC), genetic susceptibility, and CVD outcomes in individuals with diabetes remains unclear.</p>
METHODS: Data were obtained from 18 333 participants with diabetes (58.63 ± 7.54 years). The IC deficit score was categorised into five levels: 0, 1, 2, 3, and 4+. Outcomes included: hypertension, IHD, stroke, PAD, HF, and AF. Genetic risk scores (PRS) were constructed based on previously identified single nucleotide polymorphisms (SNPs) associated with these outcomes.</p>
RESULTS: Over a follow-up period of 9.91 to 13.43 years. Compared to those with an IC deficit score of 0, diabetes participants with a score of 4+ had significantly elevated risks, particularly for PAD (HR: 3.25, 95% CI: 2.44-4.33). The association between IC deficit score and IHD risk was stronger in individuals with low genetic risk. Notably, even among those with high genetic risk, an IC deficit score of 0 was linked to a lower risk of CVD outcomes.</p>
CONCLUSIONS: In individuals with diabetes, a higher IC deficit score is associated with an increased risk of hypertension, ischemic heart disease, stroke, PAD, HF, and AF.</p>
8 Authors
- Huan Chen
- Jian Gao
- Wen-Fang Zhong
- Chuan Li
- Xiao-Lin Wang
- Dan Liu
- Zhi-Hao Li
- Chen Mao
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