| Title: | Association between intrapancreatic fat deposition and osteoporosis: a cross-sectional cohort study based on the UK Biobank |
| Journal: | Chinese Journal of Digestion |
| Published: | 15 Feb 2026 |
| DOI: | https://doi.org/10.3760/cma.j.cn311367-20251113-00447 |
Publication 20850
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Abstract
Objective To investigate the correlation between intrapancreatic fat deposition(IPFD) and osteoporosis. Methods A cross-sectional cohort study was conducted on the data from the UK Biobank (UKB). A total of 35 410 participants were enrolled. The IPFD levels of all the participants were calculated according to abdominal Dixon MRI imaging results from the UKB. T score-body bone mineral density (T-BMD) were measured using dual-energy X-ray absorptiometry. Generalized linear regression models were performed to analyze the association between IPFD and T-BMD, and the confounding factors such as age, gender, ethnicity, body mass index (BMI), Townsed deprivation index, smoking history, alcohol consumption, central obesity, hyperlipidemia, and liver fat content were adjusted. Sensitivity analysis was performed by T-BMD values of the lumbar spine, left and right femoral neck and to evaluate the robustness. Results The results of linear regression analysis revealed that, after the adjustment of age, gender, ethnicity, BMI, Townsend deprivation index, central obesity, smoking history, and alcohol consumption, IPFD was significantly negatively correlated with total body T-BMD ( β =-0.012, 95% confidence interval [95% CI ]: -0.015 to -0.009, P <0.001). After further adjustment of hyperlipidemia and liver fat content, the result was still statistically significant( β =-0.010, 95% CI: -0.013 to -0.007, P <0.001). The same model was used for sensitivity analysis, and the results revealed that lumbar spine T-BMD was unrelated to IPFD( P =0.843), while T-BMD of both the left and right femoral neck were negatively correlated with IPFD(both β =-0.004, both 95% CI: -0.007 to -0.001, both P <0.05). Conclusions IPFD is negatively correlated with bone mineral density. This highlights the importance of qualitative differences in fat distribution in the assessment of metabolic health, particularly fat deposition in metabolic organs.</p>
5 Authors
- 彭钰涵
- 董小武
- 施笑蕾
- 路国涛
- 陆子鹏
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