| Title: | Healthy lifestyle as a protective factor against the risk of gastroesophageal reflux disease: Prospective population cohort analysis. |
| Journal: | PLOS ONE |
| Published: | 15 Oct 2026 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/42879421/ |
| DOI: | https://doi.org/10.1371/journal.pone.0360299 |
Publication 21510
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Abstract
BACKGROUND: Lifestyle modifications are recommended by American Gastroenterological Association (AGA) for managing gastroesophageal reflux disease (GERD), a significant health issue; but evidence is scarce. This study aims to investigate the longitudinal association between healthy lifestyle behaviors and the risk of GERD.</p>
METHODS: We analyzed data from 306,543 participants aged between 38 and 73 years without GERD at baseline from the UK Biobank. A summarized healthy lifestyle score (range, 0-7) was calculated using seven items: never smoking, healthy sleep, moderate body mass index (BMI), regular physical exercise, moderate alcohol intake, healthy diet, and moderate tea/coffee intake. Multivariable Cox regression was performed to examine the associations.</p>
RESULT: During a mean follow-up of 12.7 years, 27,943 (9.1%) GERD cases were identified. Each healthy lifestyle, except for moderate alcohol intake (hazard ratios [HR], 1.00; 95% confidence interval [CI]: 0.98-1.03) was associated with a lower risk of GERD. Relative to participants with less than 2 of summarized healthy lifestyle score, those with 2, 3, 4, and 5-7 of this score showed a significantly lower risk of GERD, with the HR of 0.94 (95% CI: 0.90-0.98), 0.83 (0.80-0.86), 0.74 (0.71-0.77), 0.63 (0.60-0.66), respectively (P for trend <0.001). Stratified analysis shows that the above associations were more pronounced among participants who were younger (< 60 years), female and employed (all P for interaction <0.05). Sensitivity analyses demonstrated similar results.</p>
CONCLUSIONS: This study highlights the importance of adherence to healthy lifestyle behaviors in reducing the prevalence of GERD in the general population.</p>
15 Keywords
- Adult
- Aged
- Alcohol Drinking
- Exercise
- Female
- Gastroesophageal Reflux
- Healthy Lifestyle
- Humans
- Male
- Middle Aged
- Proportional Hazards Models
- Prospective Studies
- Protective Factors
- Risk Factors
- United Kingdom
13 Authors
- Lei Peng
- Xueqin Li
- Jinfeng Qi
- Liming Zhang
- Zhenqing Yang
- Xucheng Wu
- Xueqing Jia
- George O Agogo
- Guoju Liu
- Kongxi Zhu
- Zuyun Liu
- Genxiang Mao
- Honglei Wu
1 Application
| Application ID | Title |
|---|---|
| 61856 | The role of biological aging in the effect of genetic and environmental factors on health outcomes |
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