| Title: | Association of Coffee Drinking With Mortality by Genetic Variation in Caffeine Metabolism: Findings From the UK Biobank |
| Journal: | JAMA Intern Med |
| Published: | 1 Aug 2018 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/29971434/ |
| DOI: | https://doi.org/10.1001/jamainternmed.2018.2425 |
Publication 2426
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Abstract
Moderate coffee consumption has been inversely associated with mortality; however, it remained unclear whether heavy intake, particularly among those with common genetic polymorphisms that impair caffeine metabolism, increases risk of mortality. In this large prospective cohort study of a half million people, we found inverse associations for coffee drinking with mortality, including among participants drinking 1 up to 8 or more cups per day. We found no differences in the coffee-mortality association when we stratified by genetic polymorphisms affecting caffeine metabolism. In conclusion, this study provides further evidence that coffee drinking can be part of a healthy diet and offers reassurance to coffee drinkers.1 Author
- Loftfield E et al.
1 Application
| Application ID | Title |
|---|---|
| 18623 | Potential interactions between coffee consumption, genetic polymorphisms, diabetes, liver and cardiovascular disease, and total and cause-specific mortality |
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