| Title: | Dissection of genetic variation and evidence for pleiotropy in male pattern baldness |
| Journal: | Nature Communications |
| Published: | 20 Dec 2018 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/30573740/ |
| DOI: | https://doi.org/10.1038/s41467-018-07862-y |
| URL: | https://www.nature.com/articles/s41467-018-07862-y.pdf |
| Citations: | 75 (22 in last 2 years) as of 8 Aug 2024 |
Publication 2905
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Abstract
Male pattern baldness (MPB) is a sex-limited, age-related, complex trait. We study MPB genetics in 205,327 European males from the UK Biobank. Here we show that MPB is strongly heritable and polygenic, with pedigree-heritability of 0.62 (SE = 0.03) estimated from close relatives, and SNP-heritability of 0.39 (SE = 0.01) from conventionally-unrelated males. We detect 624 near-independent genome-wide loci, contributing SNP-heritability of 0.25 (SE = 0.01), of which 26 X-chromosome loci explain 11.6%. Autosomal genetic variance is enriched for common variants and regions of lower linkage disequilibrium. We identify plausible genetic correlations between MPB and multiple sex-limited markers of earlier puberty, increased bone mineral density (rg = 0.15) and pancreatic β-cell function (rg = 0.12). Correlations with reproductive traits imply an effect on fitness, consistent with an estimated linear selection gradient of -0.018 per MPB standard deviation. Overall, we provide genetic insights into MPB: a phenotype of interest in its own right, with value as a model sex-limited, complex trait.</p>
9 Keywords
- Age Factors
- Alopecia
- Bone Density
- Genetic Pleiotropy
- Genetic Variation
- Humans
- Linkage Disequilibrium
- Polymorphism, Single Nucleotide
- United Kingdom
8 Authors
- Chloe X. Yap
- Julia Sidorenko
- Yang Wu
- Kathryn E. Kemper
- Jian Yang
- Naomi R. Wray
- Matthew R. Robinson
- Peter M. Visscher
1 Application
| Application ID | Title |
|---|---|
| 12505 | Dissecting the genetic basis of relationships between early-life and later-life events |
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