| Title: | A genome-wide cross-trait analysis from UK Biobank highlights the shared genetic architecture of asthma and allergic diseases |
| Journal: | Nature Genetics |
| Published: | 21 May 2018 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/29785011/ |
| DOI: | https://doi.org/10.1038/s41588-018-0121-0 |
| URL: | https://europepmc.org/articles/pmc5980765?pdf=render |
Publication 3892
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Abstract
Clinical and epidemiological data suggest that asthma and allergic diseases are associated and may share a common genetic etiology. We analyzed genome-wide SNP data for asthma and allergic diseases in 33,593 cases and 76,768 controls of European ancestry from UK Biobank. Two publicly available independent genome-wide association studies were used for replication. We have found a strong genome-wide genetic correlation between asthma and allergic diseases (rg = 0.75, P = 6.84 × 10−62). Cross-trait analysis identified 38 genome-wide significant loci, including 7 novel shared loci. Computational analysis showed that shared genetic loci are enriched in immune/inflammatory systems and tissues with epithelium cells. Our work identifies common genetic architectures shared between asthma and allergy and will help to advance understanding of the molecular mechanisms underlying co-morbid asthma and allergic diseases.</p>
8 Authors
- Zhaozhong Zhu
- Phil H. Lee
- Mark D. Chaffin
- Wonil Chung
- Po-Ru Loh
- Quan Lu
- David C. Christiani
- Liming Liang
Enabling scientific discoveries that improve human health