| Title: | Four pleiotropic loci associated with fat mass and lean mass |
| Journal: | International Journal of Obesity |
| Published: | 27 Jul 2020 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/32719433/ |
| DOI: | https://doi.org/10.1038/s41366-020-0645-0 |
| URL: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7912634 |
Publication 4861
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Abstract
BackgroundFat mass and lean mass are two biggest components of body mass. Both fat mass and lean mass are under strong genetic determinants and are correlated.MethodsWe performed a bivariate genome-wide association meta-analysis of (lean adjusted) leg fat mass and (fat adjusted) leg lean mass in 12,517 subjects from 6 samples, and followed by in silico replication in large-scale UK biobank cohort sample (N = 370 097).ResultsWe identified four loci that were significant at the genome-wide significance (GWS, α = 5.0 × 10−8) level at the discovery meta-analysis, and successfully replicated in the replication sample: 2q36.3 (rs1024137, pdiscovery = 3.32 × 10−8, preplication = 4.07 × 10−13), 5q13.1 (rs4976033, pdiscovery = 1.93 × 10−9, preplication = 6.35 × 10−7), 12q24.31 (rs4765528, pdiscovery = 7.19 × 10−12, preplication = 1.88 × 10−11) and 18q21.32 (rs371326986, pdiscovery = 9.04 × 10−9, preplication = 2.35 × 10−95). The above four pleiotropic loci may play a pleiotropic role for fat mass and lean mass development.ConclusionsOur findings further enhance the understanding of the genetic association between fat mass and lean mass and provide a new theoretical basis for their understanding.</p>
15 Authors
- Yu Liu
- Shu Ran
- Yong Lin
- Yu-Xue Zhang
- Xiao-Lin Yang
- Xin-Tong Wei
- Zi-Xuan Jiang
- Xiao He
- Hong Zhang
- Gui-Juan Feng
- Hui Shen
- Qing Tian
- Hong-Wen Deng
- Lei Zhang
- Yu-Fang Pei
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