| Title: | Genome-wide association study of serum liver enzymes implicates diverse metabolic and liver pathology |
| Journal: | Nature Communications |
| Published: | 5 Feb 2021 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/33547301/ |
| DOI: | https://doi.org/10.1038/s41467-020-20870-1 |
| URL: | https://www.nature.com/articles/s41467-020-20870-1.pdf |
Publication 5050
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Abstract
Serum liver enzyme concentrations are the most frequently-used laboratory markers of liver disease, a major cause of mortality. We conduct a meta-analysis of genome-wide association studies of liver enzymes from UK BioBank and BioBank Japan. We identified 160 previously-unreported independent alanine aminotransferase, 190 aspartate aminotransferase, and 199 alkaline phosphatase genome-wide significant associations, with some affecting multiple different enzymes. Associated variants implicate genes that demonstrate diverse liver cell type expression and promote a range of metabolic and liver diseases. These findings provide insight into the pathophysiology of liver and other metabolic diseases that are associated with serum liver enzyme concentrations.11 Authors
- Vincent L. Chen
- Xiaomeng Du
- Yanhua Chen
- Annapurna Kuppa
- Samuel K. Handelman
- Rishel B. Vohnoutka
- Patricia A. Peyser
- Nicholette D. Palmer
- Lawrence F. Bielak
- Brian Halligan
- Elizabeth K. Speliotes
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