| Title: | Mortality in Patients With Genetic and Environmental Risk of Liver Disease |
| Journal: | The American Journal of Gastroenterology |
| Published: | 8 Jun 2021 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/34131090/ |
| DOI: | https://doi.org/10.14309/ajg.0000000000001326 |
Publication 5416
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Abstract
INTRODUCTION: The increasing liver-related mortality calls for hepatic surveillance programs. To design them, factors selectively increasing liver-related vs overall mortality need to be identified.METHODS: We analyzed mortality data from 467,558 individuals recruited by the community-based UK Biobank. The mean follow-up was 11.4 years.
RESULTS: While all assessed genetic factors associated with increased liver-specific mortality, only homozygous TM6SF2 mutation and SERPINA1 mutation conferred elevated overall mortality. Among the environmental factors, obesity and metabolic syndrome disproportionately contributed to liver-related deaths.
DISCUSSION: Our data demonstrate an interplay between genetics and environment and provide a basis for hepatic surveillance programs.
5 Authors
- Carolin V. Schneider
- Malin Fromme
- Kai Markus Schneider
- Tony Bruns
- Pavel Strnad
Enabling scientific discoveries that improve human health