| Title: | Association between Cognitive Function and Depression with Human T-Cell Lymphotropic Virus 1 Seropositivity and Serointensity in UK Adults |
| Journal: | Pathogens |
| Published: | 30 Oct 2021 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/34832565/ |
| DOI: | https://doi.org/10.3390/pathogens10111409 |
| URL: | https://www.mdpi.com/2076-0817/10/11/1409/pdf |
Publication 7246
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Abstract
Several viral, bacterial, and parasitic diseases have been associated with cognitive function and neuropsychiatric outcomes in humans, including human T-cell lymphotropic virus 1 (HTLV-1). In this study, we sought to further generalize previously reported associations of cognitive function and depression with HTLV-1 seropositivity and serointensity using a community-based sample of adults aged approximately 40 to 70 years (mean = 55.3 years) from the United Kingdom. In this sample, the results of adjusted linear regression models showed no associations of HTLV-1 seropositivity or serointensity with reasoning, pairs-matching, or reaction-time cognitive tasks or with depression. In addition, neither age, sex, educational attainment, nor income moderated associations of HTLV-1 seropositivity or serointensity with cognitive function or depression. In this middle-aged to older middle-aged adult community sample, HTLV-1 seropositivity and serointensity do not appear to be associated with reasoning, pairs-matching, and reaction-time tasks or with depression.5 Authors
- Lance D. Erickson
- Dawson W. Hedges
- Bruce L. Brown
- Bradley Embley
- Shawn D. Gale
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