| Title: | Genetic predisposition, lifestyle risk, and obesity associate with the progression of nonalcoholic fatty liver disease |
| Journal: | Digestive and Liver Disease |
| Published: | 1 Aug 2021 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/34348882/ |
| DOI: | https://doi.org/10.1016/j.dld.2021.07.009 |
Publication 7455
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Abstract
BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) is prevalent worldwide. We aim to identify the factors promoting NAFLD progression.METHODS: UK Biobank study participants were diagnosed for whether NAFLD presented at baseline. Cox regression model was used to examine the association of risk factors with incident diseases (significant liver diseases [SLDs], type 2 diabetes [T2D], cardiovascular diseases [CVDs], chronic kidney diseases [CKDs], and cancers) among NAFLD cases.
RESULTS: Of 78 283 individuals, 35 159 (44.9%) were females, and the mean (SD) age was 57.56 (7.90) years. Compared with participants had both low genetic and lifestyle risk, individuals with both high genetic and lifestyle risk had a hazard ratio of 1.64 (95% CI 1.32-2.03) for SLDs, 1.16 (1.08-1.24) for T2D, 1.25 (1.13-1.37) for CVDs, 1.33 (1.18-1.49) for CKDs, and 1.13 (1.05-1.22) for cancers. Compared with participants who were non-obese and had low genetic risk, those with obesity and high genetic risk had an 75% (95% CI 38-123%), 147% (128-167%), 46% (33-61%), and 76% (56-99%) increased risk for developing SLDs, T2D, CVDs, and CKDs, respectively. The population-attributable fractions suggested that lifestyle risk and obesity contributed more to the progression of NAFLD than genetic risk.
CONCLUSION: Adhering to a healthy lifestyle and avoiding obesity are important to prevent NAFLD progression.
7 Authors
- Zhenqiu Liu
- Chen Suo
- Renjia Zhao
- Huangbo Yuan
- Li Jin
- Tiejun Zhang
- Xingdong Chen
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