| Title: | Genetic contributions to Trail Making Test performance in UK Biobank |
| Journal: | Molecular Psychiatry |
| Published: | 19 Sep 2017 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/28924184/ |
| DOI: | https://doi.org/10.1038/mp.2017.189 |
| URL: | https://kclpure.kcl.ac.uk/ws/files/102054353/Genetic_contributions_to_Trail_HAGENAARS_Accepted13July2017_GOLD_VoR_CC_BY_.pdf |
| Citations: | 22 (4 in last 2 years) as of 8 Aug 2024 |
Publication 8483
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Abstract
The Trail Making Test (TMT) is a widely used test of executive function and has been thought to be strongly associated with general cognitive function. We examined the genetic architecture of the TMT and its shared genetic aetiology with other tests of cognitive function in 23 821 participants from UK Biobank. The single-nucleotide polymorphism-based heritability estimates for trail-making measures were 7.9% (part A), 22.4% (part B) and 17.6% (part B−part A). Significant genetic correlations were identified between trail-making measures and verbal-numerical reasoning (rg>0.6), general cognitive function (rg>0.6), processing speed (rg>0.7) and memory (rg>0.3). Polygenic profile analysis indicated considerable shared genetic aetiology between trail making, general cognitive function, processing speed and memory (standardized β between 0.03 and 0.08). These results suggest that trail making is both phenotypically and genetically strongly associated with general cognitive function and processing speed.</p>
18 Keywords
- Adult
- Aged
- Biological Specimen Banks
- Biomarkers
- Cognition
- Executive Function
- Female
- Genetic Association Studies
- Humans
- Intelligence
- Male
- Middle Aged
- Multifactorial Inheritance
- Polymorphism, Single Nucleotide
- Psychometrics
- Reproducibility of Results
- Trail Making Test
- United Kingdom
10 Authors
- S P Hagenaars
- S R Cox
- W D Hill
- G Davies
- D C M Liewald
- CHARGE consortium Cognitive Working Group
- S E Harris
- A M McIntosh
- C R Gale
- I J Deary
1 Application
| Application ID | Title |
|---|---|
| 10279 | The relationship of cognitive function and negative emotions with morbidity and mortality: an aetiological investigation |
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