| Title: | Shared genetic origin of asthma, hay fever and eczema elucidates allergic disease biology |
| Journal: | Nature Genetics |
| Published: | 30 Oct 2017 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/29083406/ |
| DOI: | https://doi.org/10.1038/ng.3985 |
| URL: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5989923 |
| Citations: | 432 (100 in last 2 years) as of 8 Aug 2024 |
Publication 8495
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Abstract
This large-scale genome-wide association analysis of subjects with asthma, hay fever or eczema provides insights into the shared genetic basis of these allergic diseases. The findings suggest that these diseases partly co-occur because they share many genetic risk variants that dysregulate the expression of immune-related genes.</p>
10 Keywords
- Asthma
- Eczema
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Humans
- Hypersensitivity
- Phenotype
- Polymorphism, Single Nucleotide
- Rhinitis, Allergic, Seasonal
- Risk Factors
66 Authors
- Manuel A Ferreira
- Judith M Vonk
- Hansjörg Baurecht
- Ingo Marenholz
- Chao Tian
- Joshua D Hoffman
- Quinta Helmer
- Annika Tillander
- Vilhelmina Ullemar
- Jenny van Dongen
- Yi Lu
- Franz Rüschendorf
- Jorge Esparza-Gordillo
- Chris W Medway
- Edward Mountjoy
- Kimberley Burrows
- Oliver Hummel
- Sarah Grosche
- Ben M Brumpton
- John S Witte
- Jouke-Jan Hottenga
- Gonneke Willemsen
- Jie Zheng
- Elke Rodríguez
- Melanie Hotze
- Andre Franke
- Joana A Revez
- Jonathan Beesley
- Melanie C Matheson
- Shyamali C Dharmage
- Lisa M Bain
- Lars G Fritsche
- Maiken E Gabrielsen
- Brunilda Balliu
- Jonas B Nielsen
- Wei Zhou
- Kristian Hveem
- Arnulf Langhammer
- Oddgeir L Holmen
- Mari Løset
- Gonçalo R Abecasis
- Cristen J Willer
- Andreas Arnold
- Georg Homuth
- Carsten O Schmidt
- Philip J Thompson
- Nicholas G Martin
- David L Duffy
- Natalija Novak
- Holger Schulz
- Stefan Karrasch
- Christian Gieger
- Konstantin Strauch
- Ronald B Melles
- David A Hinds
- Norbert Hübner
- Stephan Weidinger
- Patrik K E Magnusson
- Rick Jansen
- Eric Jorgenson
- Young-Ae Lee
- Dorret I Boomsma
- Catarina Almqvist
- Robert Karlsson
- Gerard H Koppelman
- Lavinia Paternoster
1 Application
| Application ID | Title |
|---|---|
| 10074 | Investigation of the genetic burden of eczema and the genetic overlap between eczema and related conditions |
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